Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.

TL;DR: It is demonstrated that the ABCB1 3435 genotype affects angiotensin II- Stimulated serum aldosterone levels and salt-stimulated urinary sodium excretion, indicating a new link between MDR1 genotype and the ald testosterone system in humans.

TL;DR: A novel targeted proteomics method based on scheduled parallel reaction monitoring with a heavy stable isotope-labeled quantitative concatamer (QconCAT) internal protein standard for the quantification of allele-specific protein expression (ASPE) of UGT2B15, suggesting the involvement of different cis-acting variants in regulating the transcription and translation processes of the gene.

TL;DR: This paper provides an update on the current data on SNPs in genes encoding low-dose MTX membrane transport proteins and their relevance as possible biomarkers of MTX therapeutic outcome.

TL;DR: A preliminary report suggests that P-gp may play some role in male infertility, mediating detrimental effects of environmental factors.

TL;DR: A significant correlation of a polymorphism in exon 26 (C3435T) of MDR-1 with expression levels and function is observed and this polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of M DR-1.

TL;DR: Allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P‐glycoprotein function.

TL;DR: Some synonymous mutations in the human DRD2 have functional effects and suggest a novel genetic mechanism, calling into question some assumptions made about synonymous variation in molecular population genetics and gene-mapping studies of diseases with complex inheritance, and indicate that synonymous variation can have effects of potential pathophysiological and pharmacogenetic importance.

TL;DR: SNPs in MDR1 in relation to population frequencies, drug levels, and phenotypes are outlined and issues relating to M DR1 haplotypes, environmental factors, and study design, as potential confounding factors of the observed MDR 1 polymorphism effect in vivo, are discussed.