Multidrug Resistance in Bacteria
1.6K
TL;DR: This review discusses the current knowledge on the molecular mechanisms involved in both types of resistance in bacteria.
read more
Abstract: Large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in bacteria may be generated by one of two mechanisms. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This review discusses our current knowledge on the molecular mechanisms involved in both types of resistance.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Toward the computer-aided discovery of FabH inhibitors. Do predictive QSAR models ensure high quality virtual screening performance?
Yunierkis Pérez-Castillo,Yunierkis Pérez-Castillo,Maykel Cruz-Monteagudo,Cosmin Lazar,Jonatan Taminau,Jonatan Taminau,Mathy Froeyen,Miguel Ángel Cabrera-Pérez,Miguel Ángel Cabrera-Pérez,Ann Nowé +9 more
TL;DR: A ligand-based modeling methodology for the virtual-screening of large collections of chemical compounds in the search of potential FabH inhibitors and evidenced, for the first time to the authors' knowledge, the benefits of ensemble modeling in a virtual screening scenario.
The development of a human polyomavirus quantitative PCR assay to assess viral persistence, water quality, and human health risks
Shannon M. McQuaig
- 01 Jan 2009
TL;DR: A QPCR assay for the quantification of two human-specific polyomaviruses (HPyVs) in environmental water samples was developed and validated and detected in a high proportion of human-associated waste samples and were not detected in animal excrement samples.
The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs
TL;DR: In this paper , the authors provide an overview of multidrug resistance (MDR) transporters, including their classifications and structural similarities, and highlight the importance of two ATP molecules for the formation of an interface between the two binding sites of NBD domains across all these transporter.
An optimal control problem applied to plasmid-mediated antibiotic resistance
TL;DR: The results show the relevance of the synergism between the antibiotic treatment and the immune system response and the optimal control is obtained applying the Pontryagin’s Principle.
8
Phenazines: Natural products for microbial growth control
Cátia A. Sousa,Marta Ribeiro,Francisca Leticia Vale,Manuel Simões +3 more
- 01 Nov 2023
TL;DR: Phenazines, natural products produced by bacteria, exhibit antimicrobial properties by inducing oxidative stress, and phenazine-inspired antibiotics show promise in combating multidrug-resistant bacterial infections, including biofilm-related ones, through various cellular mechanisms.
8
References
UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F. Pettersen,Thomas D. Goddard,Conrad C. Huang,Gregory S. Couch,Daniel M. Greenblatt,Elaine C. Meng,Thomas E. Ferrin +6 more
TL;DR: Two unusual extensions are presented: Multiscale, which adds the ability to visualize large‐scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera session interactively despite being at separate locales.
Lateral gene transfer and the nature of bacterial innovation
TL;DR: Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through the acquisition of sequences from distantly related organisms.
Carbapenemases: the versatile beta-lactamases.
Anne Marie Queenan,Karen Bush +1 more
TL;DR: The characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria are updates and metallo-β-lactamases are detected primarily in Pseudomonas aeruginosa.
2.5K
Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Makoto Kuroda,Toshiko Ohta,Ikuo Uchiyama,Tadashi Baba,Harumi Yuzawa,Ichizo Kobayashi,Longzhu Cui,Akio Oguchi,Ken-ichi Aoki,Yoshimi Nagai,JianQi Lian,Teruyo Ito,Mutsumi Kanamori,Hiroyuki Matsumaru,Atsushi Maruyama,Hiroyuki Murakami,Akira Hosoyama,Yoko Mizutani-Ui,Noriko K. Takahashi,Toshihiko Sawano,Ryu-ichi Inoue,Chikara Kaito,Kazuhisa Sekimizu,Hideki Hirakawa,Satoru Kuhara,Susumu Goto,Junko Yabuzaki,Minoru Kanehisa,Atsushi Yamashita,Kenshiro Oshima,Keiko Furuya,Chie Yoshino,Tadayoshi Shiba,Masahira Hattori,Naotake Ogasawara,Hideo Hayashi,Keiichi Hiramatsu +36 more
TL;DR: Investigation of many newly identified gene products, including the 70 putative virulence factors, will greatly improve the understanding of the biology of staphylococci and the processes of infectious diseases caused by S aureus.
2.1K
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
Scott W. Altmann,Harry R. Davis,Li-ji Zhu,Xiaorui Yao,Lizbeth M. Hoos,Glen Tetzloff,Sai Prasad N. Iyer,Maureen Maguire,Andrei Golovko,Ming Zeng,Luquan Wang,Nicholas J. Murgolo,Michael P. Graziano +12 more
TL;DR: It is shown that Niemann-Pick C1Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol, and resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.
1.8K