Multicomponent Exercise Program Reduces Frailty and Inflammatory Biomarkers and Improves Physical Performance in Community-Dwelling Older Adults: A Randomized Controlled Trial
TL;DR: The combined center- and home-based MCEP were effective in reversing frailty to pre-frailty and improving physical performance especially balance in the older population.
read more
Abstract: The efficacy of exercise to reverse frailty in the aging population has not been extensively investigated. This study aimed to investigate the effectiveness of a multicomponent exercise program (MCEP) on frailty, physical performance (handgrip strength, Berg Balance Scale (BBS), Timed Up and Go test (TUG), and VO2Max), blood biomarkers (Interleukin-6 (IL-6) and C-reactive protein (CRP)) in frail older adults. A randomized controlled trial using an allocation concealment method, included 64 older adults (77.78 ± 7.24 years), were divided into two parallel groups using block randomization: an MCEP group (n = 32) and a control group (n = 32). The combined center- and home-based MCEP training consisted of chair aerobic, resistance, and balance, which was carried out 3 days per week for 24 weeks. A mixed model repeated measure ANOVA demonstrated significant interaction effects of group x time for BBS, TUG and frailty scores (p < 0.001). Additionally, the post-hoc analysis revealed that the MCEP group showed significantly improved BBS, TUG, and frailty scores (p < 0.01), at both 12- and 24-weeks. When compared with controls at 12-weeks, the MCEP group decreased IL-6 and CRP levels (p < 0.05). The combined center- and home-based MCEP were effective in reversing frailty to pre-frailty and improving physical performance especially balance in the older population.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society.
TL;DR: In this paper, the effects of aging on the Gut microbiota, immune system, and skeletal muscle were discussed, and nutritional recommendations to prevent malnutrition and support healthy active aging with a focus on gut microbiota were provided.
93
OUP accepted manuscript
01 Mar 2022
TL;DR: X-CircuiT was used to reverse pre-frailty in Chinese older adults and determine potential mechanisms through which pre frailty is reversed as discussed by the authors , which showed significant improvements in senior fitness indicators and body composition.
39
Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities
C. S. Trettel,Bruno Rocha de Avila Pelozin,Marcelo Paes de Barros,André Luis Lacerda Bachi,Pedro G. S. Braga,Cesar Miguel Momesso,Guilherme Eustáquio Furtado,Pedro Valente,Edilamar Menezes de Oliveira,Eef Hogervorst,Tiago Fernandes +10 more
TL;DR: In this paper , the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis is described. But the role of irisin in metabolism and inflammation remains poorly understood.
Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review
Erika Meléndez Oliva,Jorge Hugo Villafañe,Jose Luis Alonso Perez,Alexandra Alonso-Sal,Guillermo Molinero Carlier,Andrés Quevedo García,Silvia Turroni,Oliver Martínez-Pozas,Norberto Valcárcel Izquierdo,Eleuterio A. Sánchez Romero +9 more
TL;DR: The low quality of the evidence suggests that aerobic and resistance exercise during HD treatment improves systemic inflammation biomarkers in patients with ESRD, but more studies are needed to affirm solid conclusions and to make intervention parameters sufficiently clear.
References
The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.
John E. Ware,Cathy D. Sherbourne +1 more
TL;DR: A 36-item short-form survey designed for use in clinical practice and research, health policy evaluations, and general population surveys to survey health status in the Medical Outcomes Study is constructed.
37.9K
Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
22K
Frailty in elderly people
TL;DR: Developing more efficient methods to detect frailty and measure its severity in routine clinical practice would greatly inform the appropriate selection of elderly people for invasive procedures or drug treatments and would be the basis for a shift in the care of frail elderly people towards more appropriate goal-directed care.
7.6K
Exercise and physical activity for older adults
Wojtek Chodzko-Zajko,David N. Proctor,Maria A. Fiatarone Singh,Christopher T. Minson,Claudio R. Nigg,George J. Salem,James S. Skinner +6 more
TL;DR: The evidence reviewed in this Position Stand is generally consistent with prior American College of Sports Medicine statements on the types and amounts of physical activity recommended for older adults as well as the recently published 2008 Physical Activity Guidelines for Americans.
5K