Journal Article10.1016/J.LFS.2019.04.046
Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).
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TL;DR: Interventions like metformin, orlistat, hormonal contraceptives, GLP1 agonists, and VitD have been applied to ameliorate or reverse the pathological characterization of PCOS, and drug-combined therapy ofPCOS is superior to single drug administration.
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About: This article is published in Life Sciences. The article was published on 01 Jul 2019. The article focuses on the topics: Polycystic ovary syndrome (PCOS) & Polycystic ovary.
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Citations
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
H. Sadeghi,I. Adeli,Daniela Calina,Anca Oana Docea,Taraneh Mousavi,Marzieh Daniali,Shekoufeh Nikfar,Aristidis Tsatsakis,Mohammad Abdollahi +8 more
TL;DR: Understanding more about PCOS would be beneficial to find new medications implying the effect via the novel discovered routes, and it would be helpful to do further research and run well-designed clinical trials on this subject.
Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome.
TL;DR: The main symptoms of PCOS are reviewed, including neuroendocrine disorders, reproductive processes, dyslipidemia, obesity, hypertension, nonalcoholic fatty liver disease (NAFLD), and sleep disordered breathing, which seriously affect the physical and mental health ofPCOS women.
238
Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment
TL;DR: In this article , a comprehensive overview of the current progress in the efficacy of insulin sensitization therapy in the management of polycystic ovary syndrome (PCOS), providing the latest evidence for the clinical treatment of women with PCOS and IR.
Microbiome and PCOS: State-of-Art and Future Aspects.
Pierluigi Giampaolino,Virginia Foreste,Claudia Di Filippo,Alessandra Gallo,Antonio Mercorio,Paolo Serafino,Francesco Paolo Improda,Paolo Verrazzo,Giuseppe Zara,Cira Buonfantino,Maria Borgo,Gaetano Riemma,Chiara De Angelis,Brunella Zizolfi,Giuseppe Bifulco,Luigi Della Corte +15 more
TL;DR: A review of the available literature data about the relationship between microbiome and polycystic ovarian syndrome (PCOS) was performed from inception to November 20 as mentioned in this paper, where the authors focused on the connection of intestinal bacteria with sex hormones and insulin-resistance: while in the first case, a relationship with hyperandrogenism has been described, although it is still unclear, in the second one, chronic low-grade inflammation by activating the immune system, with increased production of proinflammatory cytokines which interfere with insulin receptor function, causing IR (Insulin Resistance)/hyperinsulinem
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The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
TL;DR: The comprehensive results show that, in all studies, overweight women with polycystic ovary syndrome treated with metformin had significantly improved endocrine and metabolic indicators, including testosterone, follicle-stimulating hormone, luteinizing hormone, and low-density lipoprotein cholesterol.
References
Association of the CAG repeat polymorphisms in androgen receptor gene with polycystic ovary syndrome: a systemic review and meta-analysis.
TL;DR: This meta-analysis demonstrates no evident association between the CAG length variations in AR gene and PCOS risk, while the C AG length appears to be positively associated with T levels in PCOS patients.
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Differential insulin and steroidogenic signaling in insulin resistant and non-insulin resistant human luteinized granulosa cells-A study in PCOS patients.
TL;DR: This study shows how candidate molecules that were differentially expressed, aid in designing targeted therapy against the two phenotypes of PCOS.
48
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
TL;DR: These data support a relationship between FF sRAGE and measures of ovarian reserve and Targeting AGEs might offer potential therapeutic options for the treatment of diminished ovarian response.
Fasting as possible complementary approach for polycystic ovary syndrome: Hope or hype?
Benito Chiofalo,Antonio Simone Laganà,Vittorio Palmara,Roberta Granese,Giacomo Corrado,Emanuela Mancini,Salvatore Giovanni Vitale,Helena Ban Frangež,Eda Vrtačnik-Bokal,Onofrio Triolo +9 more
TL;DR: Considering the paramount importance of InsR and compensatory hyperinsulinemia, different fasting regimens can reduce IGF-1, IGFBP1, glucose and insulin levels and consequently have beneficial effects on ovarian function, androgen excess and infertility in PCOS women.
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Insulin enhances luteinizing hormone-stimulated steroidogenesis by porcine theca cells.
TL;DR: It has been shown recently that insulin enhances differentiation of rat, pig, and human granulosa cells, and if insulin also plays a role in the regulation of theca cell steroidogenesis, then insulin action is exerted, at least in part, at a site(s) proximal to cyclic adenosine 3'5'-monophosphate (cAMP) generation.