Journal Article10.1016/J.LFS.2019.04.046
Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).
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TL;DR: Interventions like metformin, orlistat, hormonal contraceptives, GLP1 agonists, and VitD have been applied to ameliorate or reverse the pathological characterization of PCOS, and drug-combined therapy ofPCOS is superior to single drug administration.
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About: This article is published in Life Sciences. The article was published on 01 Jul 2019. The article focuses on the topics: Polycystic ovary syndrome (PCOS) & Polycystic ovary.
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Citations
The Role Played by Mitochondria in Polycystic Ovary Syndrome.
Chang Sun,Shanshan Zhao,Zimeng Pan,Jing Li,Yasong Wang,Hongying Kuang +5 more
TL;DR: Recent studies on the mechanisms of action of mitochondrial dysfunction in PCOS and its associated clinical manifestations are summarized from the perspective of tissues and organs, and some studies on the treatment of the disease by improving mitochondrial function are reviewed to highlight key role of mitochondrial dysfunction in this syndrome.
Additional file 2 of Comparative analysis of serum and saliva samples using Raman spectroscopy: a high-throughput investigation in patients with polycystic ovary syndrome and periodontitis
Wang Jian-mei,Cheng Tianfan,Li Huijun,Zhang Feng,Zhao Dan,Xu Xiaoyi,Yu Rong,Wen Ping,Cheng Yun-fei,Xu Jian,Jin Lijian,Yao Jilong +11 more
- 14 Aug 2024
Abstract: Additional file 2: Document S2. Inflammatory mediator testing protocol.
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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Stefan J. Marciniak,Chi Yun,Seiichi Oyadomari,Isabel Novoa,Yuhong Zhang,Rivka Jungreis,Kazuhiro Nagata,Heather P. Harding,David Ron +8 more
TL;DR: This work finds that CHOP directly activates GADD34, which promotes ER client protein biosynthesis by dephosphorylating phospho-Ser 51 of the alpha-subunit of translation initiation factor 2 (eIF2alpha) in stressed cells, and protects cells from ER stress by decreasing client protein load and changing redox conditions within the organelle.
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TL;DR: The results suggest that the mechanism of translation reinitiation involving uORFs is conserved from yeast to mammals.
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Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
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TL;DR: It is demonstrated that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible.
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The polycystic ovary syndrome: a position statement from the European Society of Endocrinology
Gerard S. Conway,Didier Dewailly,Evanthia Diamanti-Kandarakis,Héctor F. Escobar-Morreale,Stephen Franks,Alessandra Gambineri,Fahrettin Kelestimur,Djuro Macut,Dragan Micic,Renato Pasquali,Marija Pfeifer,Duarte Pignatelli,Michel Pugeat,Bulent O. Yildiz +13 more
TL;DR: A critical endocrine and European perspective on the debate on the definition of PCOS is offered and all major aspects related to aetiological factors, including early life events, potentially involved in the development of the disorder are summarized.