Journal Article10.1016/J.LFS.2019.04.046
Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).
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TL;DR: Interventions like metformin, orlistat, hormonal contraceptives, GLP1 agonists, and VitD have been applied to ameliorate or reverse the pathological characterization of PCOS, and drug-combined therapy ofPCOS is superior to single drug administration.
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About: This article is published in Life Sciences. The article was published on 01 Jul 2019. The article focuses on the topics: Polycystic ovary syndrome (PCOS) & Polycystic ovary.
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Citations
Causes of Polycystic Ovarian Syndrome
Sasmita Panda,Rituparna Das,Lisley Konar,Manish Kumar Singh +3 more
- 29 Apr 2024
TL;DR: PCOS etiology is unknown, but genetic, epigenetic, environmental, and gut microbiome factors are suspected. It is the most common cause of an-ovulatory infertility and has late consequences like endometrial carcinoma. More human research is required to understand the etiology of PCOS.
Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome: A systematic review and meta-analysis
Lin-Lin Chen,Jian-Hong Zheng +1 more
TL;DR: In this article, the effects of atorvastatin on insulin resistance in polycystic ovarian syndrome (PCOS) patients were evaluated in nine randomized controlled trials (RCTs) published up to August 2020.
ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression
Hui Mo,Qian Feng,Li Li,Jiahui La +3 more
TL;DR: In ovary, ApoC3 was found to be located in the cytoplasm of oocyte, and its expression gradually increased with PCOS progression, and it may be involved in PCOS progression and possibly participate in the regulation of oocyte development.
A Brief Analysis of the Treatment of Non-Obese Polycystic Ovary Syndrome from the Liver in the “Fu Qingzhu Gynecology”
TL;DR: This study analyzes the treatment of non-obese PCOS in "Fu Qingzhu Gynecology", focusing on liver-centered methods, including soothing, calming, and nourishing techniques, to provide a theoretical basis for clinical treatment of polycystic ovary syndrome patients.
Polycystic Ovary Syndrome and Sex Hormones in Bariatric Surgery Candidates.
Shiliang Dong,Saikam Law,Changrui Ou,Bian Wu,Wah Yang,Xiaoguan Zhang +5 more
References
Adiponectin and Adiponectin Receptors
TL;DR: It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Stefan J. Marciniak,Chi Yun,Seiichi Oyadomari,Isabel Novoa,Yuhong Zhang,Rivka Jungreis,Kazuhiro Nagata,Heather P. Harding,David Ron +8 more
TL;DR: This work finds that CHOP directly activates GADD34, which promotes ER client protein biosynthesis by dephosphorylating phospho-Ser 51 of the alpha-subunit of translation initiation factor 2 (eIF2alpha) in stressed cells, and protects cells from ER stress by decreasing client protein load and changing redox conditions within the organelle.
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
Krishna M. Vattem,Ronald C. Wek +1 more
TL;DR: The results suggest that the mechanism of translation reinitiation involving uORFs is conserved from yeast to mammals.
1.7K
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
Keisuke Yamamoto,Takashi Sato,Toshie Matsui,Masanori Sato,Tetsuya Okada,Hiderou Yoshida,Akihiro Harada,Kazutoshi Mori +7 more
TL;DR: It is demonstrated that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible.
1K
The polycystic ovary syndrome: a position statement from the European Society of Endocrinology
Gerard S. Conway,Didier Dewailly,Evanthia Diamanti-Kandarakis,Héctor F. Escobar-Morreale,Stephen Franks,Alessandra Gambineri,Fahrettin Kelestimur,Djuro Macut,Dragan Micic,Renato Pasquali,Marija Pfeifer,Duarte Pignatelli,Michel Pugeat,Bulent O. Yildiz +13 more
TL;DR: A critical endocrine and European perspective on the debate on the definition of PCOS is offered and all major aspects related to aetiological factors, including early life events, potentially involved in the development of the disorder are summarized.