Muller glial cell reprogramming and retina regeneration
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TL;DR: In teleost fish, the response of Müller glia to retinal injury involves a reprogramming event that imparts retinal stem cell characteristics and enables them to produce a proliferating population of progenitors that can regenerate all major retinal cell types and restore vision.
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Abstract: Muller glia in the fish retina respond to injury by reprogramming to a stem-cell-like state that enables them to regenerate all of the major retinal cell types. Goldman reviews our current understanding of the mechanisms that regulate this regenerative response and considers how this knowledge might be applied to improve repair in the mammalian retina.
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References
Regeneration of Cone Photoreceptors when Cell Ablation Is Primarily Restricted to a Particular Cone Subtype
TL;DR: A novel animal model provides control of ablation that will assist in identifying mechanisms required to replace cone photoreceptors clinically to restore daytime vision and discusses the hypothesis that, after cone death, the microenvironment formed by the remaining retinal cells may be influential in determining the identity of regenerating photoreCEPTors.
An Element in the α1-Tubulin Promoter Is Necessary for Retinal Expression during Optic Nerve Regeneration But Not after Eye Injury in the Adult Zebrafish
TL;DR: It is found that the E-box and HD sequences were necessary for transgene reinduction during optic nerve regeneration, but were not as important fortransgene expression in regenerating retinal neurons after eye injury.
The Proneural Basic Helix-Loop-Helix Gene Ascl1a Is Required for Retina Regeneration
TL;DR: The identification of a critical E-box in the α1T promoter that mediates transactivation by achaete-scute complex-like 1a (ascl1a) during retina regeneration is reported, and it is shown that as cl1a is essential for retina regeneration.
Ganglion cell regeneration following whole-retina destruction in zebrafish.
Tshering Sherpa,Shane M. Fimbel,Dianne E. Mallory,Hans Maaswinkel,Scott D. Spritzer,Jordan A. Sand,Lei Li,David R. Hyde,Deborah L. Stenkamp +8 more
TL;DR: This study provides the first documentation of functional whole retina regeneration in the zebrafish, Danio rerio, following intraocular injection of the cytotoxin, ouabain, and provides an informative view of the regenerative process.
Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration
Ryan Thummel,Jennifer M. Enright,Sean C. Kassen,Jacob E. Montgomery,Travis J. Bailey,David R. Hyde +5 more
TL;DR: It is confirmed that Müller glial-derived neuronal progenitor cells are necessary to regenerate cones and that distinct mechanisms selectively regenerate rod and cone photoreceptors in the adult zebrafish retina and increases the understanding of the molecular pathways required for photoreceptor cell regeneration.