Journal Article10.1016/S0264-410X(01)00321-8
Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity.
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TL;DR: Gag-specific cell- and antibody-mediated responses in local as well as systemic lymphoid tissues following intranasal (IN) immunizations with PLG-DNA but not with naked DNA are found, which have important implications for DNA vaccine development.
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About: This article is published in Vaccine. The article was published on 12 Nov 2001. The article focuses on the topics: Naked DNA & DNA vaccination.
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Citations
Vaccine adjuvants: current challenges and future approaches.
Jennifer H. Wilson-Welder,Maria P. Torres,Matt J. Kipper,Surya K. Mallapragada,Michael J. Wannemuehler,Balaji Narasimhan +5 more
TL;DR: A comprehensive discussion is presented of current vaccine adjuvants, their effects on the induction of immune responses, and vaccine adjUVants that have shown promise in recent literature.
298
Microparticles for the delivery of DNA vaccines
TL;DR: The background and rationale for microparticles as a vaccine delivery system, data demonstrating their utility and mode of action for DNA delivery, and the prospects for their development are reviewed.
139
Recent advances in mucosal vaccines and adjuvants.
Kristina Eriksson,Jan Holmgren +1 more
TL;DR: Mucosal vaccines may be used both to prevent mucosal infections through the activation of antimicrobial immunity and to treat systemic inflammatory diseases through the induction of antigen-specific mucosal tolerance.
134
The long-term potential of biodegradable poly(lactide- co - glycolide) microparticles as the next-generation vaccine adjuvant
TL;DR: With strategic development of PLG-based vaccines, PLG microparticles can offer advantages over the conventional vaccine adjuvants allowing commercial development of this adjuvant.
117
Plasmid DNA- and messenger RNA-based anti-cancer vaccination.
TL;DR: This review focuses on the utilization of vaccines based on plasmid DNA (pDNA) and messenger RNA (mRNA) coding for tumor associated antigens, and the current knowledge on anti-tumor vaccination based on MNAV-encoded tumor Antigens is discussed.
109
References
Cationic microparticles: A potent delivery system for DNA vaccines
TL;DR: An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection, and induced significantly enhanced serum antibody responses in comparison to naked DNA.
Impaired mucosal immune responses in interleukin 4-targeted mice.
TL;DR: The data suggest that IL-4-/- mice are unable to respond to oral/mucosal immunization due to a failure to stimulate antigen-specific cells required to induce germinal center reactions in the Peyer's patches.
Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines.
TL;DR: The adjuvant effect of PLG microparticles are discussed, and their potential for the development of single-dose vaccines through the use of controlled-release technology is discussed.
Improving protein therapeutics with sustained-release formulations
Scott D. Putney,Paul A. Burke +1 more
TL;DR: Using injectable depot formulaions in which the protein is encapsulated in, and released slowly from, microspheres made of biodegradable polymers can justify commercial development of proteins that, for a variety of reasons, could not be marketed as solution formulations.
•Book
New Generation Vaccines
Graeme C. Woodrow,Myron M. Levine +1 more
- 01 Nov 1990
TL;DR: Vaccines and Vaccination in Historical Perspective, Myron M. Levine, Rosanna Lagos, and Jose' Esparza Developing Vaccines in the Era of Reverse Vaccinology, Rino Rappuoli, Gordon Dougan, and Isabel Delany Initial Clinical Evaluation of New Vaccine Candidates.