Mucosal immunity and vaccines
Jan Holmgren,Cecil Czerkinsky +1 more
TL;DR: The properties of the mucosal immune system are reviewed and advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders are discussed.
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Abstract: There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders.
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Citations
Pentabody-mediated antigen delivery induces antigen-specific mucosal immune response.
Shenghua Li,Wenju Zheng,Rhonda KuoLee,Tomoko Hirama,Matthew J. Henry,Shokouh Makvandi-Nejad,Ted Fjällman,Wangxue Chen,Jianbing Zhang +8 more
TL;DR: It was found that one construct was equivalent to CT in helping induce mucosal immune response, providing some insight into the controversial role of CTB in mucosal immunization: at least for BSA, the model antigen BSA employed in this study, CTB has to be tightly linked to the antigen to have adjuvant/immune-enhancing effect.
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Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity
TL;DR: A review of the recent findings that address the promising potential of sublingual immunization in proving protection against various mucosal pathogens.
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B Epitope Multiplicity and B/T Epitope Orientation Influence Immunogenicity of Foot-and-Mouth Disease Peptide Vaccines
Esther Blanco,Carolina Cubillos,Noelia Moreno,Juan Bárcena,Beatriz G. de la Torre,David Andreu,Francisco Sobrino +6 more
TL;DR: It is shown that multivalency is advantageous over simple B-T-epitope juxtaposition, resulting in efficient induction of neutralizing antibodies and optimal release of IFNγ, and useful insights for a more accurate design of FMD subunit vaccines are provided.
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TL;DR: SC/SC immunization resulted in a significant increase in the neutralizing capacity of serum antibodies towards Efb and LukMF’, shown by increased phagocytosis of S. aureus and increased viability of bovine leukocytes.
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