Mucosal immunity and vaccines
Jan Holmgren,Cecil Czerkinsky +1 more
TL;DR: The properties of the mucosal immune system are reviewed and advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders are discussed.
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Abstract: There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders.
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Citations
Comparison of systemic and mucosal vaccination: impact on intravenous and rectal SIV challenge
Diane L. Bolton,Kaimei Song,Robert L. Wilson,Pamela A. Kozlowski,Georgia D. Tomaras,Brandon F. Keele,Rachel V. Lovingood,Srinivas S. Rao,Mario Roederer +8 more
TL;DR: The similar outcomes achieved by systemic and airway mucosal immunization support AE delivery as a safe, effective, and less invasive alternative to parenteral vaccination.
41
Mucosal Immunization with Liposome-Nucleic Acid Adjuvants Generates Effective Humoral and Cellular Immunity
TL;DR: It is suggested that liposome-nucleic acid adjuvants represent a promising new class of mucosal adjuvant for non-replicating vaccines, with notable efficiency at eliciting both humoral and cellular immune responses following intranasal administration.
41
Sampling of the Intestinal Microbiota by Epithelial M Cells
TL;DR: Several recent advances in understanding of specialized epithelial M cells are discussed, including signals controlling their development, the mechanisms they use for taking up microbes, and their exploitation by certain pathogens.
41
Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model.
Gabriel K. Pedersen,Diane Major,Sarah Roseby,John Wood,Abdullah S. Madhun,Rebecca Jane Cox,Rebecca Jane Cox +6 more
TL;DR: It is shown that the Matrix‐M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model and the vaccine itself is safe and effective in both a classical and a naive model.
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Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV-1 gp140 vaccination in mice.
Griet A. Van Roey,Mauricio A. Arias,John S. Tregoning,John S. Tregoning,George Rowe,Robin J. Shattock,Robin J. Shattock +6 more
TL;DR: This is the first time that TSLP has been demonstrated to have a positive effect as a mucosal adjuvant, and specifically to promote mucosal and systemic responses to HIV gp140.
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