Mucins, Mucus, and Goblet Cells

TL;DR: The identified ENU-induced mutation in the mouse Ryk gene which causes goblet cell hyperplasia in the lung is identified, and RYK plays important roles in maintaining the balance between airway epithelial cell populations during development and repair, and that defects in RYk expression or function may contribute to the pathogenesis of human lung diseases.

TL;DR: Coated sodium butyrate and vitamin D3 supplementation improve gut health in early-stage broilers by influencing intestinal immunity, barrier, and microflora.

TL;DR: In this paper , a brain and muscle ARNT-like 1 (BMAL1) knockdown 16HBE cell line was constructed to analyze the effects of rhythmic fluctuations on mucin expression.

TL;DR: In this paper , the authors investigated the mechanisms underlying the action of interleukin-6 neutralizing antibody (IL-6 Ab) in attenuating airway mucus hypersecretion in COPD, human and mouse primary bronchial epithelial cells from COPD patients and mice were isolated.

TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.

TL;DR: The colon mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer, usually approximately 100 μm thickness as measured in mouse.

TL;DR: Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects.

TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.