Journal Article10.1016/J.CHEST.2017.11.008
Mucins, Mucus, and Goblet Cells
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TL;DR: Insight into the innate immune properties of mucins and goblet cells support a shift from the current paradigm of repressing increased mucin expression to targeting regulation of specific mucins or mucin hyperconcentration in the abnormal airway milieu.
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About: This article is published in Chest. The article was published on 21 Nov 2017. The article focuses on the topics: Mucin & Goblet cell.
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Citations
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.
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TL;DR: Muc5b increased earlier and more abundantly than Muc5ac during experimental primary infection suggesting an acute defensive response against Pneumocystis as described against bacteria, while increased MUC5ac levels supports an ongoing allergic, Th2 lymphocyte-type response during primary Pneumocytestis infection.
Additional file 1 of Analysis of the association of ANO3/MUC15, COL4A4, RRBP1, and KLK1 polymorphisms with COPD susceptibility in the Kashi population
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Abstract: Additional file 1. The uncropped image details of the location of SNV rs5516.
Hidden cell diversity in Placozoa: Ultrastructural Insights from Hoilungia hongkongensis
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TL;DR: The diversity of cell types in placozoans is indeed higher than anticipated, and several morphologically distinct and potentially novel cell types are recognized, among them novel gland cells and “shiny spheres”-bearing cells at the upper epithelium.
The Effect of Particulate Matter Exposure on the Inflammatory Airway Response of Street Runners and Sedentary People
Lucas Guimarães Pagani,Juliana de Melo Batista dos Santos,Roberta Foster,Marcelo N. Rossi,Luiz Antonio Luna Junior,Catherine Machado Katekaru,Matheus Cavalcante de Sá,Anne-Charlotte Jonckheere,Francine Maria de Almeida,Jônatas Bussador do Amaral,Rodolfo de Paula Vieira,Dominique Bullens,André Luis Lacerda Bachi,Mauro Vaisberg +13 more
TL;DR: Outdoor endurance training acts as an inducer of a differentiated immune response in the upper airways of runners compared to individuals with a sedentary lifestyle from the same community after elevated PM exposure.
CD147 increases mucus secretion induced by cigarette smoke in COPD
TL;DR: Increased CD147 levels induced by CS extract could stimulate MUC5AC secretion through the MMP9 and p38 MAPK signaling pathway in HBE cells, and regulation of CD147 could be a promising target for mucus hypersecretion in COPD.
References
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
Maria van der Sluis,Barbara A. E. de Koning,Adrianus C. J. M. de Bruijn,Anna Velcich,Jules P.P. Meijerink,Johannes B. van Goudoever,Hans A. Büller,Jan Dekker,Isabelle Van Seuningen,Ingrid B. Renes,Alexandra W. C. Einerhand +10 more
TL;DR: This study shows that Muc2 deficiency leads to inflammation of the colon and contributes to the onset and perpetuation of experimental colitis.
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TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
TL;DR: The colon mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer, usually approximately 100 μm thickness as measured in mouse.
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Azithromycin for Prevention of Exacerbations of COPD
Richard K. Albert,Richard K. Albert,John E. Connett,William C. Bailey,Richard Casaburi,J. Allen D. Cooper,Gerard J. Criner,Jeffrey L. Curtis,Mark T. Dransfield,MeiLan K. Han,Stephen C. Lazarus,Barry J. Make,Nathaniel Marchetti,Fernando J. Martinez,Nancy E. Madinger,Charlene McEvoy,Dennis E. Niewoehner,Janos Porsasz,Connie S. Price,Connie S. Price,John J. Reilly,Paul D. Scanlon,Frank C. Sciurba,Steven M. Scharf,George R. Washko,Prescott G. Woodruff,Nicholas R. Anthonisen +26 more
TL;DR: Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects.
A common MUC5B promoter polymorphism and pulmonary fibrosis
Max A. Seibold,Anastasia L. Wise,Marcy C. Speer,Mark P. Steele,Kevin K. Brown,James E. Loyd,Tasha E. Fingerlin,Weiming Zhang,Gunnar Gudmundsson,Steve D. Groshong,Christopher M. Evans,Stavros Garantziotis,Kenneth B. Adler,Burton F. Dickey,Roland M. du Bois,Ivana V. Yang,Aretha Herron,Dolly Kervitsky,Janet Talbert,Cheryl Markin,Joungjoa Park,Anne L. Crews,Susan Slifer,Scott S. Auerbach,Michelle G. Roy,Jia Lin,Corinne E. Hennessy,Marvin I. Schwarz,David A. Schwartz +28 more
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
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