Mucins, Mucus, and Goblet Cells

TL;DR: This review explores the concept of "united airway diseases", highlighting the interaction between upper and lower respiratory diseases through epidemiological, histoembryological, neural, microbiological, and clinical studies, revealing a complex chain reaction of inflammatory factors.

TL;DR: In this article , a combination of oral and topical sobrerol could benefit children and adults with frequent respiratory tract infections, based on the concept that mucus accumulation could be a risk factor for increased susceptibility to infections.

TL;DR: The cells associated with the immune system in the intestinal mucosa of al paca play an important role in protecting against foreign microbial invasion and infection, and this result provides a theoretical basis for revealing the occurrence of gastrointestinal diseases in alpaca.

TL;DR: In this paper, primers were designed to amplify and isolate a candidate region for the bovine MUC2 promoter, which was confirmed by sequencing and cloned into a plasmid vector containing the luciferase (LUC) reporter gene, since it was able to induce expression of a reporter gene in an in vitro cell culture experimental platform.

TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.

TL;DR: The colon mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer, usually approximately 100 μm thickness as measured in mouse.

TL;DR: Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects.

TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.