Journal Article10.1016/J.CHEST.2017.11.008
Mucins, Mucus, and Goblet Cells
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TL;DR: Insight into the innate immune properties of mucins and goblet cells support a shift from the current paradigm of repressing increased mucin expression to targeting regulation of specific mucins or mucin hyperconcentration in the abnormal airway milieu.
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About: This article is published in Chest. The article was published on 21 Nov 2017. The article focuses on the topics: Mucin & Goblet cell.
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Citations
Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo
Zhuya Yang,Xiaohong Li,Rongbing Fu,Min Hu,Yingjie Wei,Xuhong Hu,Wen Cai Tan,Xiaoyun Tong,Feng Huang +8 more
TL;DR: Renifolin F attenuated AHR and airway inflammation in the OVA-induced asthmatic mouse model by inhibiting the regulation of ILC2s in the lung, thereby, reducing the upstream inflammatory cytokines IL-25, IL-33 and TSLP and the co-stimulatory factors IL-2 and IL-7.
Muc5b Contributes to Mucus Abnormality in Rat Models of Cystic Fibrosis
Johnathan D Keith,Alexander G Henderson,Courtney M. Fernandez-Petty,Joy M. Davis,Ashley M Oden,Susan E. Birket +5 more
TL;DR: Data indicate that accumulation of Muc5b initiates the muco-obstructive process in the CF lung prior to infection.
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Endoplasmic reticulum stress/XBP1 promotes airway mucin secretion under the influence of neutrophil elastase.
TL;DR: In this paper, the effect of ER stress on neutrophil elastase (NE)induced mucin (MUC)5AC production in human airway epithelial cells was explored.
Oxidative stress induces MUC5AC expression through mitochondrial damage‐dependent STING signaling in human bronchial epithelial cells
Yutaka Nishida,Hisako Yagi,Masaya Ota,Atsushi Tanaka,Koichiro Sato,Takaharu Inoue,Satoshi Yamada,Naoya Arakawa,Takashi Ishige,Yasuko Kobayashi,Hirokazu Arakawa,Takumi Takizawa +11 more
TL;DR: In this article , the role of innate immunity in mucin production in airway epithelial cells under oxidative stress was investigated, showing that mitochondria and STING play important roles in producing mucin in response to oxidative stress.
6
A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics
Joseph Burclaff,R. Jarrett Bliton,Keith A. Breau,Meryem T. Ok,Ismael Gomez-Martinez,Jolene S. Ranek,Aadra P. Bhatt,Jeremy E. Purvis,John T. Woosley,Scott T. Magness +9 more
TL;DR: In this paper, single-cell transcriptomics covering the duodenum, jejunum, ileum, and ascending, transverse, and descending colon from 3 humans was presented.
References
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
Maria van der Sluis,Barbara A. E. de Koning,Adrianus C. J. M. de Bruijn,Anna Velcich,Jules P.P. Meijerink,Johannes B. van Goudoever,Hans A. Büller,Jan Dekker,Isabelle Van Seuningen,Ingrid B. Renes,Alexandra W. C. Einerhand +10 more
TL;DR: This study shows that Muc2 deficiency leads to inflammation of the colon and contributes to the onset and perpetuation of experimental colitis.
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Airway mucus function and dysfunction.
John V. Fahy,Burton F. Dickey +1 more
TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
TL;DR: The colon mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer, usually approximately 100 μm thickness as measured in mouse.
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Azithromycin for Prevention of Exacerbations of COPD
Richard K. Albert,Richard K. Albert,John E. Connett,William C. Bailey,Richard Casaburi,J. Allen D. Cooper,Gerard J. Criner,Jeffrey L. Curtis,Mark T. Dransfield,MeiLan K. Han,Stephen C. Lazarus,Barry J. Make,Nathaniel Marchetti,Fernando J. Martinez,Nancy E. Madinger,Charlene McEvoy,Dennis E. Niewoehner,Janos Porsasz,Connie S. Price,Connie S. Price,John J. Reilly,Paul D. Scanlon,Frank C. Sciurba,Steven M. Scharf,George R. Washko,Prescott G. Woodruff,Nicholas R. Anthonisen +26 more
TL;DR: Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects.
A common MUC5B promoter polymorphism and pulmonary fibrosis
Max A. Seibold,Anastasia L. Wise,Marcy C. Speer,Mark P. Steele,Kevin K. Brown,James E. Loyd,Tasha E. Fingerlin,Weiming Zhang,Gunnar Gudmundsson,Steve D. Groshong,Christopher M. Evans,Stavros Garantziotis,Kenneth B. Adler,Burton F. Dickey,Roland M. du Bois,Ivana V. Yang,Aretha Herron,Dolly Kervitsky,Janet Talbert,Cheryl Markin,Joungjoa Park,Anne L. Crews,Susan Slifer,Scott S. Auerbach,Michelle G. Roy,Jia Lin,Corinne E. Hennessy,Marvin I. Schwarz,David A. Schwartz +28 more
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
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