mTOR signaling at a glance

TL;DR: This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of R g3 on angiogenesis, and raises the possibility that Rg 3 is a prodrug.

TL;DR: Data indicate that the modulation of autophagy in peripheral nerve injury could be an effective pharmacological approach to promote nerve regeneration and reestablish motor function.

TL;DR: This review addresses the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms and suggests greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed.

TL;DR: This work genetically engineered Rictor ablation or overexpression in mouse and human HER2-amplified breast cancer models and found that mTORC2 uses two coordinated pathways to activate cell invasion/motility, both of which converge on Rac1.

TL;DR: In this paper, the rictor-mTOR complex was used to identify compounds which modulate Akt activity mediated by the Rictor mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activation.

TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.

TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.

TL;DR: It is reported that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels.