mTOR signaling at a glance
TL;DR: The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival.
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Abstract: The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. Discoveries that have been made over the last decade show that the mTOR pathway is activated
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Citations
Muscle Wasting Diseases: Novel Targets and Treatments.
TL;DR: An overview of the current knowledge of the key mechanisms involved in muscle wasting conditions and novel pharmacological avenues that could ameliorate muscle diseases is provided.
The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity.
TL;DR: This study highlights the importance of the AKT/mTOR signaling pathway in statin-induced myotoxicity and reveals potential drug targets for treatment of patients withstatin-associated myopathies.
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Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms.
Inan Olmez,Breanna Brenneman,Aizhen Xiao,Vlad Serbulea,Mouadh Benamar,Ying Zhang,Laryssa Manigat,Tarek Abbas,Jeongwu Lee,Ichiro Nakano,Jakub Godlewski,Agnieszka Bronisz,Roger Abounader,Norbert Leitinger,Benjamin Purow +14 more
TL;DR: The findings demonstrate that the combination of CDK4/6 and mTOR inhibition has therapeutic potential against GBM and suggest it should be evaluated in a clinical trial.
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The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses
TL;DR: The current knowledge of mTOR, as related to the immune microenvironment and immune responses is summarized.
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Gut microbiota and mTOR signaling: Insight on a new pathophysiological interaction.
TL;DR: How this emerging field of research gives a beautiful insight into how the mentioned cross-talk impacts the body's homeostasis is discussed, leading to undesirable complications including obesity, diabetes, colon and pancreatic cancer, immune system malfunctioning and ageing.
85
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Do Hyung Kim,Dos D. Sarbassov,Siraj M. Ali,Jessie E. King,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is reported that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels.
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