mTOR signaling at a glance
TL;DR: The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival.
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Abstract: The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. Discoveries that have been made over the last decade show that the mTOR pathway is activated
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Citations
•Journal Article
Genetic alterations and PIK3CA gene mutations and amplifications analysis in cervical cancer by racial groups in the United States.
TL;DR: Whether the PIK3CA gene mutations and amplifications in cervical cancer differ across racial/ethnic groups in the United States is investigated to explore as therapeutic targets to improve cervical cancer treatment.
22
Placental DEPTOR as a stress sensor during pregnancy.
Dionisis Mparmpakas,Elena Zachariades,Anastasia G. Goumenou,Anastasia G. Goumenou,Yori Gidron,Emmanouil Karteris +5 more
TL;DR: The hypothesis that maternal stress can affect mTOR signalling at term, and, as a result, influence placental growth is tested and appears to be indicative of a higher order of complexity of DEPTOR signalling in the human placenta that is affected by maternal stress, which could affect pregnancy outcome.
Network analysis of gene expression in peripheral blood identifies mTOR and NF-κB pathways involved in antipsychotic-induced extrapyramidal symptoms.
TL;DR: The analysis revealed that, in response to AP treatment, constructed networks were enriched for different biological processes in patients without EPS compared with those presenting EPS, and involved specific pathways, such as anaphase promoting complex /cdc20, prefoldin/CCT/triC and ATP synthesis in no-EPS patients.
22
Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression.
TL;DR: In this article, the role and mechanisms for n-3 PUFAs in protecting against kidney fibrosis remain obscure, however, the correlation between the deficiency of omega-3 polyunsaturated fatty acids and the progression of chronic kidney diseases (CKD) is revealed.
The host mTOR pathway and parasitic diseases pathogenesis.
Sajad Rashidi,Reza Mansouri,Mohammad Ali-Hassanzadeh,Zahra Mojtahedi,Reza Shafiei,Amir Savardashtaki,Nasrin Hamidizadeh,Mohammadreza Karimazar,Paul Nguewa,Raúl Manzano-Román +9 more
TL;DR: In this paper, a review underlines the implications of mTOR signals and intricate networks on pathogen infections and the modulation of this master regulator by parasites, and the identification of parasite effects and interactions over such a complex modulation might reveal novel information regarding the biology of the abovementioned parasites and might allow the development of therapeutic strategies against parasitic diseases.
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Dana M. Gwinn,David B. Shackelford,Daniel F. Egan,Maria M. Mihaylova,Annabelle Mery,Debbie S. Vasquez,Benjamin E. Turk,Reuben J. Shaw +7 more
TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.
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Do Hyung Kim,Dos D. Sarbassov,Siraj M. Ali,Jessie E. King,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is reported that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels.
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