Journal Article10.1039/B111551K
Morphine, the Proteus of organic molecules
Paul R. Blakemore,James D. White +1 more
119
TL;DR: This feature article encapsulates the senior author's longstanding interests in opiate chemistry and attempts to place it within an historical context and against the backdrop of related work by others who have viewed morphine as one of the pinnacles of natural product synthesis.
read more
About: This article is published in Chemical Communications. The article was published on 17 May 2002.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Basic opioid pharmacology: an update
Hasan Pathan,John P. Williams +1 more
TL;DR: Most clinically relevant opioid analgesics bind to MOP receptors in the central and peripheral nervous system in an agonist manner to elicit analgesia.
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.
TL;DR: Salinosporamide A serves as an intriguing example of the successful interplay of modern drug discovery and biomedical research, medicinal chemistry and pharmacology, natural product synthesis and analysis, as well as biosynthesis and bioengineering.
Structural Simplification of Natural Products
TL;DR: A number of successful examples leading to marketed drugs or drug candidates will be discussed in detail to illustrate how structural simplification is applied in lead optimization of NPs.
189
Pd-catalyzed enantioselective allylic substitution: new strategic options for the total synthesis of natural products.
TL;DR: The enantioselective version of palladium-catalyzed allylic substitution, sometimes referred to as AAA (asymmetric allylic alkylation), has emerged as a powerful synthetic tool and has recently proven to be of particular value as they react with cyclic substrates of type 1 and 2.
160
References
Purification and properties of 1,2-dehydroreticuline reductase from Papaver somniferum seedlings
TL;DR: 1, 2-Dehydroreticuline reductase, the NADPH-dependent enzyme which reduces stereospecifically 1,2-dehydro reticulines to ( R )-reticULine has been discovered in seedlings of the opium poppy and has been purified to apparent electrophoretic homogeneity.