Journal Article10.1038/NRI1733
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
read more
Abstract: Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result of the specialization of tissue macrophages in particular microenvironments. Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of this is not completely understood. However, as we discuss here, recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues. These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs.
Makon-Sébastien Njock,Makon-Sébastien Njock,Henry S. Cheng,Henry S. Cheng,Lan T.H. Dang,Lan T.H. Dang,Maliheh Nazari-Jahantigh,Andrew C. Lau,Andrew C. Lau,Emilie Boudreau,Emilie Boudreau,Mark Roufaiel,Mark Roufaiel,Myron I. Cybulsky,Myron I. Cybulsky,Andreas Schober,Jason E. Fish,Jason E. Fish +17 more
TL;DR: It is revealed that ECs secrete EVs that can modulate monocyte activation and suggest that altered EV secretion and/or microRNA content may affect vascular inflammation in the setting of cardiovascular disease.
262
IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis.
Qi Cao,Yiping Wang,Dong Zheng,Yan Sun,Ya Wang,Vincent W. Lee,Guoping Zheng,Thian Kui Tan,Jon Ince,Stephen I. Alexander,David Harris +10 more
TL;DR: It is demonstrated that IL-10/TGF-beta-modified macrophages effectively protect against renal injury in AN and may become part of a therapeutic strategy for chronic inflammatory disease.
260
Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.
Diana Mittag,Anna I Proietto,Thomas Loudovaris,Stuart I. Mannering,David Vremec,Ken Shortman,Li Wu,Leonard C. Harrison +7 more
TL;DR: It is indicated that human blood DC closely resemble human spleen DC, and parallels between human and mouse DC subsets in phenotype and function are confirmed, but differences in transcription factor and TLR expression as well as functional properties are identified.
260
Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
TL;DR: It is reported that induction of brown adipogenesis by β3-adrenergic receptor (ADRB3) activation involves the death of white adipocytes and their removal by M2-polarized macrophages, which may explain the timing of progenitor activation and the fate of these cells in vivo.
259
miR-125a-5p regulates differential activation of macrophages and inflammation.
Sami Banerjee,Huachun Cui,Na Xie,Zheng Tan,Shanzhong Yang,Mert Icyuz,Victor J. Thannickal,Edward Abraham,Gang Liu +8 more
TL;DR: The data suggest that miR-125a-5p has an important role in suppressing classical activation of macrophages while promoting alternative activation and targeting KLF13, a transcriptional factor that has anImportant role in T lymphocyte activation and inflammation.
258
References
Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
6.4K
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
6.1K
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
TL;DR: Cultured DCs are as efficient as antigen-specific B cells in presenting tetanus toxoid (TT) to specific T cell clones and their efficiency of antigen presentation can be further enhanced by specific antibodies via FcR- mediated antigen uptake.
5.5K
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
3.5K