Journal Article10.1038/NRI1733
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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Abstract: Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result of the specialization of tissue macrophages in particular microenvironments. Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of this is not completely understood. However, as we discuss here, recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues. These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes.
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TL;DR: The inflammatory response after renal injury that leads to fibrosis in relation to non-inflammatory mechanisms is discussed and a connection between fibrotic events involving inflammatory and non- inflammatory glomerulonephritis, inflammatory cell infiltration, and podocyte loss is discussed.
298
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Filipa C. Simões,Thomas J. Cahill,Amy Kenyon,Daria Gavriouchkina,Daria Gavriouchkina,Joaquim M. Vieira,Xin Sun,Daniela Pezzolla,Christophe Ravaud,Eva Masmanian,Michael Weinberger,Sarah Mayes,Madeleine E. Lemieux,Damien N. Barnette,Mala Gunadasa-Rohling,Ruth M. Williams,David R. Greaves,Le A. Trinh,Scott E. Fraser,Sarah L. Dallas,Robin P. Choudhury,Tatjana Sauka-Spengler,Paul R. Riley +22 more
TL;DR: An evolutionarily-conserved function of macrophages is identified that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.
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