Journal Article10.1038/NRI1733
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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Abstract: Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result of the specialization of tissue macrophages in particular microenvironments. Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of this is not completely understood. However, as we discuss here, recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues. These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes.
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New insights into the multidimensional concept of macrophage ontogeny, activation and function
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Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials.
Bryan N. Brown,Ricardo Londono,Stephen Tottey,Li Zhang,Kathryn A. Kukla,Matthew T. Wolf,Kerry A. Daly,Janet E. Reing,Stephen F. Badylak +8 more
TL;DR: There is a strong correlation between the early macrophage response to implanted materials and the outcome of tissue remodeling and the results of the present study suggest that the constructive remodeling outcome may be due to the recruitment and survival of different cell populations to the sites of remodeling associated with materials that elicit an M1 vs. M2 response.
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Comparison of gene expression profiles between human and mouse monocyte subsets
Molly A. Ingersoll,Rainer Spanbroek,Claudio Lottaz,Emmanuel L. Gautier,Marion Frankenberger,Reinhard Hoffmann,Roland Lang,Muzlifah Haniffa,Matthew Collin,Frank Tacke,Andreas J. R. Habenicht,Loems Ziegler-Heitbrock,Gwendalyn J. Randolph +12 more
TL;DR: Whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice.
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Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.
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