Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
Hyukjin Lee,Abigail K. R. Lytton-Jean,Yi Chen,Kevin T. Love,Angela I. Park,Emmanouil D. Karagiannis,Alfica Sehgal,William Querbes,Christopher Zurenko,Muthusamy Jayaraman,Chang G. Peng,Klaus Charisse,Anna Borodovsky,Muthiah Manoharan,Jessica S. Donahoe,Jessica Truelove,Matthias Nahrendorf,Robert Langer,Daniel G. Anderson +18 more
TL;DR: In this paper, a tetrahedral DNA strand self-assembles into tetrahedron nanoparticles that can deliver small interfering RNA molecules to cells and suppress genes in tumours.
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Abstract: DNA strands can self-assemble into tetrahedral nanoparticles that can deliver small interfering RNA molecules to cells and suppress genes in tumours.
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