Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
Hyukjin Lee,Abigail K. R. Lytton-Jean,Yi Chen,Kevin T. Love,Angela I. Park,Emmanouil D. Karagiannis,Alfica Sehgal,William Querbes,Christopher Zurenko,Muthusamy Jayaraman,Chang G. Peng,Klaus Charisse,Anna Borodovsky,Muthiah Manoharan,Jessica S. Donahoe,Jessica Truelove,Matthias Nahrendorf,Robert Langer,Daniel G. Anderson +18 more
TL;DR: In this paper, a tetrahedral DNA strand self-assembles into tetrahedron nanoparticles that can deliver small interfering RNA molecules to cells and suppress genes in tumours.
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Abstract: DNA strands can self-assemble into tetrahedral nanoparticles that can deliver small interfering RNA molecules to cells and suppress genes in tumours.
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Programming Receptor Clustering with DNA Probabilistic Circuits for Enhanced Natural Killer Cell Recognition
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Recent Advances in Engineering Carriers for siRNA Delivery.
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•Journal Article
Gene Silencing and DNA Methylation
TL;DR: The immense impact of the discovery of RNA interference (RNAi) on biomedical research and its novel medical applications in the future are reviewed in this article, with particular stress on therapeutic applications of radio-labeled antisense oligonucleotides (RASONs) for diagnosis and treatment of various cancers and neurodegenerative diseases by “gene silencing”.
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Promising strategies employing nucleic acids as antimicrobial drugs
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Self-assembling smart materials for biomaterials applications
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TL;DR: Self-assemble of biomaterials from theory to implementation will provide a broad overview of this promising phenomenon in future biomaterial applications and the applications of self-assembled smart materials and the effect of external stimuli are discussed.
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