Journal Article10.1039/C6AY00810K
Molecularly imprinted polymer-based solid phase extraction combined high performance liquid chromatography for determination of fluoroquinolones in milk
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TL;DR: In this paper, a method combining molecularly imprinted polymer-solid phase extraction (MIP-SPE) and high performance liquid chromatography was developed to determine the residues of fluoroquinolone drugs in milk.
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Abstract: In this study, a method combining molecularly imprinted polymer-solid phase extraction (MIP-SPE) and high performance liquid chromatography was developed to determine the residues of fluoroquinolone drugs in milk. During the experiments, different templates, functional monomers, porogens and template/monomer ratios were evaluated. The norfloxacin based MIP capable of recognizing four fluoroquinolones (ciprofloxacin, norfloxacin, enrofloxacin and lomefloxacin) was used to prepare the SPE cartridge. The MIP-SPE cartridge showed high adsorption capacities (≥4520 ng) and high recoveries (≥96%) to the four drugs, and could be reused for at least fifty times. Then the four drugs were fortified into blank milk samples respectively to be analyzed. The limits of detection were in the range of 10–20 ng mL−1 and the recoveries were in the range of 76.8–97.7% with coefficients of variation lower than 8.3%. Furthermore, the MIP-SPE cartridge showed a better purification effect than three commercial SPE cartridges. This is the first study reporting the use of norfloxacin based MIP-SPE for determination of fluoroquinolones in milk.
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Citations
Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review
TL;DR: In this article, a comprehensive review of recent reports in the environmental and biomedical fields, with a focus on electrochemical and optical signaling mechanisms, is presented, aiming to identify knowledge gaps that hinder the translation of MIP-based technology from research laboratories to commercialization.
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Magnetic graphene dispersive solid phase extraction combining high performance liquid chromatography for determination of fluoroquinolones in foods.
TL;DR: This magnetic graphene-based dispersive solid phase extraction method showed high absorption capacities and high enrichment factors and could be used as a simple and sensitive tool to determine the residues of fluoroquinolones in foods of animal origin.
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An automated magnetic dispersive micro-solid phase extraction in a fluidized reactor for the determination of fluoroquinolones in baby food samples.
Christina Vakh,Marcel Alaboud,Sofya Lebedinets,D. V. Korolev,Viktor N. Postnov,Leonid Moskvin,O. M. Osmolovskaya,Andrey Bulatov +7 more
TL;DR: An automated magnetic dispersive micro-solid phase extraction procedure in a fluidized reactor was developed for the determination of fluoroquinolone antimicrobial drugs in meat-based baby food samples and the results were compared with those obtained by the reference method.
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One-pot preparation of magnetic carbon adsorbent derived from pomelo peel for magnetic solid-phase extraction of pollutants in environmental waters.
TL;DR: Under the optimized extraction conditions, the MCMPs displayed satisfactory extraction performance for target analytes and was combined with HPLC-DAD for the sensitive determination of parabens and FQs in real-life water samples.
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Dual-dummy-template molecularly imprinted polymer combining ultra performance liquid chromatography for determination of fluoroquinolones and sulfonamides in pork and chicken muscle
TL;DR: In this paper, a dual-dummy-template molecularly imprinted polymer capable of simultaneous recognizing 8 fluoroquinolones and 8 sulfonamides was synthesized and compared with computational simulation.
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