Molecular stool testing for the early detection of colorectal cancer: swan song for p53?
Gia Ferretti,Alessandra Felici,Mariangela Ciccarese,Paola Papaldo,Paolo Carlini,A. Fabi,Alain Gelibter,Francesco Cognetti +7 more
About: This article is published in Annals of Oncology. The article was published on 01 Jun 2006. and is currently open access. The article focuses on the topics: Colorectal cancer.
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References
Genetic alterations during colorectal-tumor development.
Bert Vogelstein,Eric R. Fearon,Stanley R. Hamilton,Scott E. Kern,Ann C. Preisinger,Mark Leppert,A M Smits,Johannes L. Bos +7 more
TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
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Allelotype of colorectal carcinomas
Bert Vogelstein,Eric R. Fearon,Scott E. Kern,Stanley R. Hamilton,Ann C. Preisinger,Yusuke Nakamura,Ray White +6 more
TL;DR: In addition to its implications concerning the genetic events underlying tumorigenesis, tumor allelotype may provide a molecular tool for improved estimation of prognosis in patients with colorectal cancer.
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Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel.
David A. Ahlquist,Joel Skoletsky,Kevin A. Boynton,Jonathan J. Harrington,Douglas W. Mahoney,William Pierceall,Stephen N. Thibodeau,Anthony P. Shuber +7 more
TL;DR: Assay of altered DNA holds promise as a stool screening approach for colorectal neoplasia, and sensitivities for cancer were unchanged but decreased slightly for adenomas, while specificity increased to 100%.
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The TP53 Colorectal Cancer International Collaborative Study on the Prognostic and Predictive Significance of p53 Mutation: Influence of Tumor Site, Type of Mutation, and Adjuvant Treatment
TL;DR: Analysis of TP53 mutations from a large cohort of CRC patients has identified tumor site, type of mutation, and adjuvant treatment as important factors in determining the prognostic significance of this genetic alteration.
Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets
Seung Myung Dong,Giovanni Traverso,Constance M. Johnson,Li Geng,Reyna Favis,Kevin A. Boynton,Kenji Hibi,Steven N. Goodman,Matthew D'Allessio,Philip B. Paty,Stanley R. Hamilton,David Sidransky,Francis Barany,Bernard Levin,Anthony P. Shuber,Kenneth W. Kinzler,Bert Vogelstein,Jin Jen,Jin Jen +18 more
TL;DR: Three genetic targets-TP53, BAT26, and K-RAS-were used to detect tumor-associated mutations in the stool prior to or without regard to the molecular analyses of the paired tumors, able to detect the majority of colorectal cancers by analyzing stool DNA for just three genetic markers.
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