Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
Kinya Otsu,Huntington F. Willard,Vijay K. Khanna,Francesco Zorzato,N M Green,David H. MacLennan +5 more
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TL;DR: Analysis of predicted secondary structures and hydropathy plots suggests that the two isoforms exhibit the same topology in both transmembrane and cytoplasmic domains, and suggests that a modulator binding domain in the protein lies between residues 2619 and 3016.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 Aug 1990. and is currently open access. The article focuses on the topics: Ryanodine receptor & Ryanodine receptor 2.
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Citations
Endoplasmic reticulum and the control of Ca2+ homeostasis.
Jacopo Meldolesi,Antonello Villa +1 more
TL;DR: Control of Ca2+ homeostasis is one of the fundamental activities of eukaryotic cells and in the extracellular medium the concentration of the free ion is maintained in the millimolar range whereas in the cytosol the resting value is approximately four orders of magnitude lower, yet the total calcium content per cell amounts to several millimoles per liter.
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Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.
TL;DR: Immunohistochemical study showed colocalizaton of immunoreactivities for three types of proteins, D1DRs and GABAB receptor R1 and R2 subunits in the same neuronal bodies, suggesting that the neurochemical changes induced by the activation of D1 DRs andGABAB receptors occur in theSame neurons.
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Regulation of Ca2+-Release Channels by Luminal Ca2+
Ilse Sienaert,Humbert De Smedt,Jan B. Parys,Ludwig Missiaen +3 more
- 01 Jan 1998
TL;DR: The general structure of InsP3Rs and RyRs with their large cytoplasmic domains is compatible with a role of these Ca2+ channels as integrators of a large number of cellular mediators.
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