Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
Kinya Otsu,Huntington F. Willard,Vijay K. Khanna,Francesco Zorzato,N M Green,David H. MacLennan +5 more
635
TL;DR: Analysis of predicted secondary structures and hydropathy plots suggests that the two isoforms exhibit the same topology in both transmembrane and cytoplasmic domains, and suggests that a modulator binding domain in the protein lies between residues 2619 and 3016.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 Aug 1990. and is currently open access. The article focuses on the topics: Ryanodine receptor & Ryanodine receptor 2.
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Citations
Ionic Strength Dependence of Calcium, Adenine Nucleotide, Magnesium, and Caffeine Actions on Ryanodine Receptors in Rat Brain
TL;DR: Results indicate that ionic strength is an important consideration in binding studies of brain ryanodine receptors and their interactions with modulatory agents.
16
Basic and clinical insights in catecholaminergic (familial) polymorphic ventricular tachycardia
Manlio F. Márquez,Armando Totomoch-Serra,Angélica Rueda,José Everardo Avelino-Cruz,Antonio Gallegos-Cortez +4 more
TL;DR: A brief review of the genetic and molecular mechanisms of this intriguing disease is provided and gene testing is a Class I recommendation for patients with suspected CPVT.
Improper Remodeling of Organelles Deputed to Ca2+ Handling and Aerobic ATP Production Underlies Muscle Dysfunction in Ageing.
TL;DR: In this paper, the authors discuss the importance of the proper architecture of organelles and membrane systems involved in the mechanisms introduced above for the correct skeletal muscle function, which is controlled by intracellular Ca2+ concentration and by efficient production of energy (ATP), which, in turn, depend on: (a) the release and re-uptake of ca2+ from sarcoplasmic-reticulum (SR) during excitation-contraction (EC) coupling, which controls the contraction and relaxation of sarcomeres; (b) the uptake of Ca
SH oxidation stimulates calcium release channels (ryanodine receptors) from excitable cells.
Cecilia Hidalgo,Cecilia Hidalgo,Ricardo Bull,Juan José Marengo,Claudio F. Perez,Paulina Donoso +5 more
TL;DR: It is proposed that channel redox state controls the high affinity sites responsible for calcium activation as well as the low affinity sites involved in Mg2+ inhibition of channel activity.
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Patent
Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) and uses thereof
Andrew R. Marks,Donald W. Landry,Shi Xian Deng,Cheng Zhen Zhuang +3 more
- 22 Mar 2005
TL;DR: In this paper, a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation was presented.
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