Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
Kinya Otsu,Huntington F. Willard,Vijay K. Khanna,Francesco Zorzato,N M Green,David H. MacLennan +5 more
635
TL;DR: Analysis of predicted secondary structures and hydropathy plots suggests that the two isoforms exhibit the same topology in both transmembrane and cytoplasmic domains, and suggests that a modulator binding domain in the protein lies between residues 2619 and 3016.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 Aug 1990. and is currently open access. The article focuses on the topics: Ryanodine receptor & Ryanodine receptor 2.
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Citations
Molecular dissection, tissue localization and Ca2+ binding of the ryanodine receptor of Caenorhabditis elegans.
TL;DR: A model for the functional domains of CeRyR is proposed, which agrees well with the model of mammalian skeletal RyR, which is based on proteolysis and cross-linking analysis.
30
Themes and Variations in ER/SR Calcium Release Channels: Structure and Function
Peter B. Stathopulos,Min-Duk Seo,Masahiro Enomoto,Fernando J. Amador,Noboru Ishiyama,Mitsuhiko Ikura +5 more
TL;DR: A common ancestor found in unicellular genomes underscores the fundamentality of these elements to Ca(2+) release channels.
Expression of the cardiac ryanodine receptor in the compensated phase of hypertrophy in rat heart.
Françoise Rannou,Grégoire Dambrin,Isabelle Marty,François Carré,Pascal Trouvé,Anne Marie Lompré,Danièle Charlemagne +6 more
TL;DR: The results suggest that, as for SR Ca(2+)-ATPase, there is either a downregulation or a lack of upregulation of the gene coding for the Ry2 in compensatory hypertrophy.
28
Intracellular Signaling and Phasic Myometrial Contractions
Mark Phillippe,Edward K. Chien +1 more
TL;DR: In this article, a review of the intracellular signal transduction mechanisms involved in the generation of phasic contractions occurring in myometrial tissue is presented, where the presence of cell surface receptors for classic uterotonic agonists (including oxytocin, norepinephrine, vasopressin, acetylcholine and prostaglandins [PGs]) has been well described; all are seven-membrane-spanning, G protein-coupled receptors.
28
Patent
Agents for preventing and treating disorders involving modulation of the ryr receptors
Andrew R. Marks,Donald W. Landry,Shi-Xian Deng,Cheng Zhen Zhuang,Stephan E. Lehnart +4 more
- 17 Aug 2006
TL;DR: In this article, the authors provide compounds of Formula I, (I) and salts, hydrates, solvates, complexes, and prodrugs thereof, as well as methods for synthesizing compounds of formula I.
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