Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
Kinya Otsu,Huntington F. Willard,Vijay K. Khanna,Francesco Zorzato,N M Green,David H. MacLennan +5 more
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TL;DR: Analysis of predicted secondary structures and hydropathy plots suggests that the two isoforms exhibit the same topology in both transmembrane and cytoplasmic domains, and suggests that a modulator binding domain in the protein lies between residues 2619 and 3016.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 Aug 1990. and is currently open access. The article focuses on the topics: Ryanodine receptor & Ryanodine receptor 2.
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Citations
Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle.
TL;DR: It is concluded that inotropic effects of adrenaline in rat heart are mediated mainly by α1B‐adrenoceptors via release of Ca2+ from an intracellular pool via voltage‐operated channels.
FKBP12 modulation of the binding of the skeletal ryanodine receptor onto the II-III loop of the dihydropyridine receptor.
Fiona M. O’Reilly,Mylène Robert,Istvan Jona,Csaba Szegedi,Mireille Albrieux,Sandrine Geib,Michel De Waard,Michel Villaz,Michel Ronjat +8 more
TL;DR: A direct interaction of the RyR1 with the discrete domain of skeletal DHPR alpha(1)-subunit corresponding to Thr(671)-Leu(690) is demonstrated and it is shown that the association of FKBP12 withRyR1 specifically modulates this interaction.
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A Postulated Role of the Near Amino-terminal Domain of the Ryanodine Receptor in the Regulation of the Sarcoplasmic Reticulum Ca2+ Channel *
TL;DR: It is proposed that domains 1 and 1–2 of the RyR, to which these activating peptides correspond, would interact with one or more other domains within theRyR (including presumably the Ca2+-binding domain) to regulate theCa2+channel.
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Detection of a novel mutation at amino acid position 614 in the ryanodine receptor in malignant hyperthermia.
Kathleen A. Quane,H Ording,Katherine E. Keating,Bernadette M. Manning,R Heine,D. Bendixen,K. Berg,R Krivosic-Horber,F Lehmann-Horn,T. Fagerlund,Tommie V. McCarthy +10 more
TL;DR: A G to T transition mutation which results in the replacement of a conserved arginine at position 614 with a leucine (Leu) is identified in malignant hyperthermia susceptible (MHS) and central core disease (CCD) cases.
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Spatiotemporal dynamics of Ca2+ signaling and its physiological roles.
Masamitsu Iino
- 01 Jan 2010
TL;DR: Ca2+ oscillations are an efficient mechanism in regulating cell functions, having effects supra-proportional to the sum of duration of Ca2+ increase and has been used to identify hitherto unrecognized functions of Ca 2+ signals.
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