Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins.
Tommy Hlaing,Ren Feng Guo,Kari A. Dilley,Jennifer M. Loussia,Tammy A. Morrish,Michael M. Shi,Michael M. Shi,Claudius Vincenz,Peter A. Ward +8 more
157
TL;DR: The deduced amino acid sequences of two alternately spliced isoforms, designated DEFCAP-L and -S, that differ in 44 amino acids and encode a novel member of the mammalian Ced-4 family of apoptosis proteins are reported, suggesting its regulation may elucidate the complex nature of the mammals apoptosis-promoting machinery.
read more
About: This article is published in Journal of Biological Chemistry. The article was published on 23 Mar 2001. and is currently open access. The article focuses on the topics: Cyclic nucleotide-binding domain & Src homology domain.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
TL;DR: In this article, the inflammasome is identified as a caspase-activating complex that comprises caspases-1, casp-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs.
5.7K
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
TL;DR: Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge, and a review presents and integrates recent progress in the field.
NODs: intracellular proteins involved in inflammation and apoptosis.
Naohiro Inohara,Gabriel Núñez +1 more
TL;DR: Mammalian NOD proteins seem to function as cytosolic sensors for the induction of apoptosis, as well as for innate recognition of microorganisms and regulation of inflammatory responses.
1K
NF-kappaB signaling pathways in mammalian and insect innate immunity
Neal S. Silverman,Tom Maniatis +1 more
TL;DR: Recent advances in understanding the signaling pathways in mammalian and Drosophila innate immunity are discussed, with emphasis on the mechanisms by which NFB/Rel family proteins are activated.
Pyroptosis: A new frontier in cancer.
Yuan Fang,Shengwang Tian,Yutian Pan,Wei Li,Qiming Wang,Yu Tang,Tao Yu,Xi Wu,Yongkang Shi,Pei Ma,Yongqian Shu +10 more
TL;DR: The mechanism of regulating pyroptosis in tumor cells as well as the potential roles of pyroPTosis in cancer are focused on to explore potential diagnostic markers in cancers contributing to the prevention and treatment in cancers.
880
References
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
16.6K
Genomic sequencing
George M. Church,Walter Gilbert +1 more
TL;DR: The genomic sequencing procedures are applicable to the analysis of genetic polymorphisms, DNA methylation at deoxycytidines, and nucleic acid-protein interactions at single nucleotide resolution.
8.5K
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Peng Li,Deepak Nijhawan,Imawati Budihardjo,Srinivasa M. Srinivasula,Manzoor Ahmad,Emad S. Alnemri,Xiaodong Wang +6 more
TL;DR: Mutation of the active site of caspase-9 attenuated the activation of cazase-3 and cellular apoptotic response in vivo, indicating that casp enzyme-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.
7.5K
Apoptosis in the pathogenesis and treatment of disease
TL;DR: In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death, and recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases.
6.8K
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
TL;DR: The purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3, leading to apoptosis is reported here.
3.3K