Patent
Molecular Antigen Array
Wolfgang A. Renner,Martin F. Bachmann,Alain Tissot,Patrick Maurer,Franziska Lechner,Peter Sebbel,Christine Piossek +6 more
- 21 Jan 2002
175
TL;DR: In this paper, a composition comprising an AP205 virus like particle (VLP) and an antigen is presented, which is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
read more
Abstract: The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
Martin F. Bachmann,Tazio Storni,Patrick Maurer,Alain Tissot,Katrin Schwarz,Edwin Meijerink,Gerad Lipowsky,Paul Pumpens,Indulis Cielens,Regina Renhofa +9 more
- 16 Sep 2002
TL;DR: In this article, it was shown that DNA oligonucleotides containing non-methylated C and G (CpGs) can be loaded with immunostimulatory substances and induce enhanced B and T cell responses.
163
Patent
In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
Martin F. Bachmann,Franziska Lechner,Taizo Storni +2 more
- 16 Sep 2002
TL;DR: In this article, the authors found that APC activation using substances such as anti-CD40 antibodies or DNA oligomers rich in non-methylated C and G (CpGs) can dramatically enhance the specific T cell response obtained after vaccination with recombinant virus like particles (VLPs) coupled, fused or attached to antigens.
121
Patent
Controlled release of immunosuppressants from synthetic nanocarriers
David H. Altreuter,Aaron P. Griset,Roberto A. Maldonado +2 more
- 27 Apr 2012
TL;DR: In this article, synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods are described, which may also include antigen in some embodiments.
120
Patent
Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
Martin F. Bachmann,Andreas Cornelius,Vania Manolova,Patrik Maurer,Edwin Meijerink,Karl G. Proba,Katrin Schwarz +6 more
- 25 Mar 2004
TL;DR: In this paper, it was shown that DNA oligonucleotides containing non-methylated C and G (CpGs) can be loaded with immunostimulatory substances and induce enhanced B and T cell responses.
97
Patent
Tolerogenic synthetic nanocarriers to reduce immune responses to therapeutic proteins
Christopher Fraser,Takashi Kei Kishimoto,Roberto A. Maldonado +2 more
- 27 Apr 2012
TL;DR: In this article, synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.
96
References
Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
8.3K
•Book
Culture of Animal Cells
R. Ian Freshney
- 01 Jan 1983
TL;DR: Biology of Cultured Cells, Design and Layout, and Organotypic Culture: Problems Solving.
5.9K
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
TL;DR: It is demonstrated that inhibition of the action of an angiogenic factor spontaneously produced by tumour cells may suppress tumour growth in vivo.
4K
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
Frederique Bard,Catherine Cannon,Robin Barbour,Rae Lyn Burke,Dora Games,Henry Grajeda,Teresa Guido,Kang Hu,Jiping Huang,Kelly Johnson-Wood,Karen Khan,Dora Kholodenko,Michael K. Lee,Ivan Lieberburg,Ruth Motter,Minh Nguyen,Ferdie Soriano,Vasquez Nicki J,Kim Weiss,Brent Welch,Peter Seubert,Dale Schenk,Ted Yednock +22 more
TL;DR: Results indicate that antibodies can cross the blood–brain barrier to act directly in the central nervous system and should be considered as a therapeutic approach for the treatment of Alzheimer disease and other neurological disorders.
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Conrad C. Bleul,Michael Farzan,Hyeryun Choe,Cristina Parolin,Cristina Parolin,Ian Clark-Lewis,Joseph Sodroski,Timothy A. Springer +7 more
TL;DR: Testing of potential receptors demonstrated that SDF-1 signalled through, and hence 'adopted', the orphan receptor LESTR, which is therefore designated CXC-chemokine receptor-4 (CXCR-4).
2.1K
Related Papers (5)
Ruxandra Gref,Yoshiharu Minamitake,Robert Langer +2 more
- 23 Jul 1993
Miguel A. De Los Rios,Kenneth J. Oh +1 more
- 25 May 2005