Modulators of N-methyl-D-aspartate protect against diazepam- or phenobarbital-resistant cocaine convulsions.

TL;DR: Inactive doses of the neuroactive steroids markedly enhanced the anticonvulsant effects of diazepam against pentylenetetrazol without significantly increasing motor toxicity.

TL;DR: The purpose of this article is to review the primary interactions of cocaine and the effects that these interactions trigger, and the progression of symptoms observed in cocaine poisoning as they relate to serum cocaine concentrations.

TL;DR: Preclinical models of behavioral and toxic effects of cocaine are reviewed and their potential for predicting compounds with efficacy and safety in the medical management of cocaine abuse and toxicity is assessed.

TL;DR: This study provides the first description of the effectiveness of new antiepileptic drugs against experimentally induced cocaine seizures and points to several drugs that deserve clinical scrutiny for this indication.

TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.

TL;DR: The earliest known use of cocaine, as suggested by the finding of coca leaves in the tombs of Indian mummies, was in 600 A.D, but it was not until 1855 that cocaine was isolated from the leaves.

TL;DR: In this article--the first of two to focus on the neurological dangers inherent in excitatory amino acid pathways--Raymond Dingledine, Chris McBain and James McNamara consider their involvement in epilepsy; next month's article will cover brain damage following ischemia and hypoxia.

TL;DR: The extent to which compounds produce PCP-like behavioral effects might depend in part on the specific component of theNMDA receptor complex with which they interact: i.e., the NMDA receptor, the NMda receptor-associated ion channel or the glycine-sensitive modulatory site.