Modulation of interaction forces between bilayers exposing short-chained ethylene oxide headgroups.
319
TL;DR: A systematic study using the Surface Forces Apparatus to measure directly the interactions between two phosphatidyl ethanolamine lipid bilayers, finding that the force becomes repulsive at all separations and that the thickness of the steric barrier could be controlled easily by adjusting the concentration of the modified lipids.
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About: This article is published in Biophysical Journal. The article was published on 01 May 1994. and is currently open access. The article focuses on the topics: Surface forces apparatus & Bilayer.
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References
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
TL;DR: The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM1, awell‐described glycolipid with this activity.
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Measurement of forces between two mica surfaces in aqueous electrolyte solutions in the range 0–100 nm
TL;DR: The main results and conclusions of experimental measurements of the forces between molecularly smooth mica surfaces in aqueous electrolyte solutions are as follows: as mentioned in this paper, and they are based on the following assumptions:
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Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
Demetrios Papahadjopoulos,Theresa M. Allen,Alberto Gabizon,E Mayhew,Katherine K. Matthay,Shi Kun Huang,Karim Lee,M C Woodle,D D Lasic,C Redemann +9 more
TL;DR: Liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs and have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.
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