Journal Article10.1016/J.NEUROSCIENCE.2004.05.040
Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress.
Hongxin Dong,Brian Goico,Maureen V. Martin,Cynthia A. Csernansky,Amy Bertchume,John G. Csernansky +5 more
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TL;DR: The results suggest that Tg2576 mice, a mouse model of Alzheimer disease, have an impaired ability to generate new cells in the dentate gyrus of the hippocampus and that the magnitude of this impairment can be modulated by behavioral interventions and drugs known to have effects on hippocampal neurogenesis in normal rodents.
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About: This article is published in Neuroscience. The article was published on 01 Jan 2004. The article focuses on the topics: Dentate gyrus & Hippocampal formation.
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Citations
Mechanisms and functional implications of adult neurogenesis.
TL;DR: The factors that regulate proliferation and fate determination of adult neural stem cells are discussed and the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease is addressed.
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Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease
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TL;DR: Several lines of investigation support the notion that the synaptic pathology and defective neurogenesis in AD are related to progressive accumulation of Abeta oligomers rather than fibrils.
Neurogenesis and Exercise: Past and Future Directions
TL;DR: An overview of research pertaining to exercise-induced cell genesis, its possible relevance to memory function and the cellular mechanisms that may be involved in this process is given.
683
The role of adult hippocampal neurogenesis in brain health and disease
TL;DR: A possible link between the physiological functions of adult-born neurons and their roles in pathological conditions is reviewed.
578
Alzheimer disease models and human neuropathology: similarities and differences.
TL;DR: The APP transgenic mice have raised new questions concerning the mechanisms of neuronal loss, the accumulation of Aβ in the cell body of the neurons, inflammation and gliosis, and the dendritic alterations, and some insight is gained into the kinetics of the changes.
References
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Christine Sturchler-Pierrat,Dorothee Abramowski,Mairead Duke,Karl-Heinz Wiederhold,Claudia Mistl,Sabin Rothacher,Birgit Ledermann,Kurt Bürki,Peter Frey,Paolo Paganetti,Caroline Waridel,Michael E. Calhoun,Mathias Jucker,Alphonse Probst,Matthias Staufenbiel,Bernd Sommer +15 more
TL;DR: These mice resemble major features of AD pathology and suggest a central role of A beta in the pathogenesis of the disease.
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Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs
Michael S. Kaplan,James W. Hinds +1 more
TL;DR: Three-month-old rats were injected intraperitoneally with [3H]thymidine and labeled cells in the granular layers of dentate gyrus and olfactory bulb were confirmed as neurons by electron microscopy of reembedded 1-micrometer sections.
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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
Leigh A. Holcomb,Marcia N. Gordon,Eileen McGowan,Xin Yu,Stan Benkovic,Paul T. Jantzen,Kristal Wright,Irene Saad,Ryan Mueller,Dave Morgan,Sunny Sanders,Cindy Zehr,Kassandra O'Campo,John Hardy,Cristian Mihail Prada,Chris Eckman,Steven G. Younkin,Karen Hsiao,Karen Duff +18 more
TL;DR: The development of AD-like pathology is substantially enhanced when a P51 mutation, which causes a modest increase in Aβ42(43), is introduced into Tg2576-derived mice, and both doubly and singly transgenic mice showed reduced spontaneous alternation performance in a “Y” maze before substantial Aβ deposition was apparent.
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Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
TL;DR: The majority of newly born cells in the adult dentate gyrus differentiate into neurons, and cells that were immunoreactive for glial fibrillary acidic protein typically showed morphologic characteristics of radial glia at all time-points.
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Unbiased stereological estimation of the number of neurons in the human hippocampus
TL;DR: The total numbers of neurons in five subdivisions of human hippocampi were estimated using unbiased Stereological principles and systematic sampling techniques to address the problems associated with the results and conclusions of previous quantitative studies.
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