Journal Article10.1002/ADSC.201301128
Modular Synthesis of Ar-BINMOL-Phos for Catalytic Asymmetric Alkynylation of Aromatic Aldehydes with Unexpected Reversal of Enantioselectivity
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About: This article is published in Advanced Synthesis & Catalysis. The article was published on 26 May 2014. The article focuses on the topics: Enantioselective synthesis.
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References
Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral amino alcohol-based ligands
TL;DR: A series of binaphthyl-derived amino alcohols were synthesized and used as catalytic ligands in the asymmetric alkynylation of aromatic aldehydes in the presence of a dialkylzinc reagent as discussed by the authors.
86
Reversal of enantioselectivity in the hydroformylation of styrene with [2S,4S-BDPP]Pt(SnCl3)Cl at high temperature arises from a change in the enantioselective-determining step.
TL;DR: These deuterioformylation results establish that platinum hydride addition to styrene is largely irreversible at 39 degrees C but reversible at 98 degrees C, with enantioselectivity not being fully determined until the final hydrogenolysis of a platinum acyl intermediate.
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Highly enantioselective alkyne additions to aldehydes in the presence of 1,1'-bi-2-naphthol and hexamethylphosphoramide.
Ge Gao,Ru-Gang Xie,Lin Pu +2 more
TL;DR: The mild condition for the formation of the alkynylzinc reagent enables the use of functional alkynes in this asymmetric reaction with excellent enantioselectivity.
80
Low Ligand Loading, Highly Enantioselective Addition of Phenylacetylene to Aromatic Ketones Catalyzed by Schiff-Base Amino Alcohols
TL;DR: Sch Schiff-base amino alcohols 7a,b derived from L-phenylglycine through three simple steps are found to be highly effective for the enantioselective addition of phenylacetylene to aromatic ketones.
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Calcium-BINOL: a novel and efficient catalyst for asymmetric Michael reactions
TL;DR: In this article, a new calcium-BINOL catalyst was developed for asymmetric Michael addition reactions of enones and enals, which functions not only as a Lewis acid but also acts as a Bronsted base.
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