Mitophagy: An Emerging Role in Aging and Age-Associated Diseases.
TL;DR: There is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer and therapeutic interventions aiming at the induction of mitophile may have the potency to ameliorate these dysfunctions.
read more
Abstract: Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation of mitochondrial DNA (mtDNA) mutations, increased production of mitochondrial reactive oxygen species (ROS) and the consequent oxidative damage to nucleic acids, proteins and lipids. Mitophagy, a mitochondrial quality control mechanism enabling the degradation of damaged and superfluous mitochondria, prevents such detrimental effects and reinstates cellular homeostasis in response to stress. To date, there is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer. Therapeutic interventions aiming at the induction of mitophagy may have the potency to ameliorate these dysfunctions. In this review, we summarize recent findings on mechanisms controlling mitophagy and its role in aging and the development of human pathologies.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
- 19 Apr 2011
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
975
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
João A. Amorim,Giuseppe Coppotelli,Anabela P. Rolo,Carlos M. Palmeira,Jaime M. Ross,David A. Sinclair +5 more
TL;DR: The role of mitochondria in the development of diseases associated with ageing, such as neurodegenerative and cardiovascular diseases, has been recognized not merely as being energy suppliers, but also as having an essential role in developing diseases as mentioned in this paper .
474
Selective autophagy of intracellular organelles: recent research advances.
Wen Li,Wen Li,Pengcheng He,Yuge Huang,Yi-Fang Li,Jia-Hong Lu,Min Li,Hiroshi Kurihara,Zhuo Luo,Tian Meng,Mashun Onishi,Changle Ma,Lei Jiang,Yongquan Hu,Qing Gong,Dongxing Zhu,Yiming Xu,Rong Liu,Lei Liu,Cong Yi,Yushan Zhu,Ningfang Ma,Koji Okamoto,Zhiping Xie,Jinbao Liu,Rong-Rong He,Du Feng +26 more
TL;DR: The 'cargo-ligand-receptor' model in selective autophagy for specific organelles or cellular components in yeast and mammals is emphasized, with a focus on mitophagy and ER-phagy, which are finely described as types of selective autophile.
341
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".
TL;DR: The aim of the present review was to summarize experimental data and clinical observations that linked the pathophysiology mechanisms of “inflamm-aging”, mild-grade inflammation, and cytokine storm in some elderly adults with severe COVID-19 infection.
Mitophagy in degenerative joint diseases
TL;DR: The potential of targeting mitophagy for the treatment of degenerative joint diseases is highlighted and strategies by the regulation ofMitophagy exert beneficial effects in the pre-clinical experiments.
289
References
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
TL;DR: In this manuscript, the relevant progress about the role of autophagy in the pathogenesis of ocular diseases is reviewed and pharmacological manipulation of Autophagy may provide an alternative therapeutic target for some Ocular diseases.
Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
5.4K
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy
Stefano De Cillà,Serena Farruggio,Stela Vujosevic,Giulia Raina,Davide Filippini,Valentina Gatti,Nausicaa Clemente,David A.S.G. Mary,Diego Vezzola,Giamberto Casini,Luca Rossetti,Elena Grossini +11 more
TL;DR: Aflibercept and Ranibizumab protect RPE against peroxidation through the modulation of NO release, apoptosis and autophagy, and counteracted the changes of apoptosis/autophagy markers, NOS, Phosphatidylinositol-3-Kinase/Protein Kinase B and Extracellular signal–regulated kinases 1/2 caused byperoxidation.
Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Bryan E. Snow,Joan Mangion,Etienne Jacotot,Paola Costantini,Markus Loeffler,Nathanael Larochette,David R. Goodlett,Ruedi Aebersold,David P. Siderovski,Josef M. Penninger,Guido Kroemer +14 more
TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
4.3K
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
TL;DR: The mechanism of mitochondrial RIRR highlights the central role of mitochondria-formed ROS, and all of the known ROS-producing sites and their relevance to the mitochondrial ROS production in vivo are discussed.
4.1K
Related Papers (5)
Evandro Fei Fang,Yujun Hou,Konstantinos Palikaras,Bryan A. Adriaanse,Jesse S. Kerr,Beimeng Yang,Sofie Lautrup,Mahdi Hasan-Olive,Domenica Caponio,Xiuli Dan,P Rocktäschel,Deborah L. Croteau,Mansour Akbari,Nigel H. Greig,Tormod Fladby,Hilde Nilsen,M Z Cader,Mark P. Mattson,Nektarios Tavernarakis,Nektarios Tavernarakis,Vilhelm A. Bohr,Vilhelm A. Bohr +21 more