Mitochondrial dysfunction in obesity.
Juan C. Bournat,Chester W. Brown +1 more
TL;DR: The review highlights recent findings regarding the functions of mitochondria in adipocytes, providing an understanding of their central roles in regulating substrate metabolism, energy expenditure, disposal of reactive oxygen species, and in the pathophysiology of obesity and insulin resistance, as well as roles in the mechanisms that affect adipogenesis and mature adipocyte function.
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Abstract: Purpose of the Review
The review highlights recent findings regarding the functions of mitochondria in adipocytes, providing an understanding of their central roles in regulating substrate metabolism, energy expenditure, disposal of reactive oxygen species (ROS), and in the pathophysiology of obesity and insulin resistance, as well as roles in the mechanisms that affect adipogenesis and mature adipocyte function.
read more
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Citations
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies.
Prasenjit Manna,Sushil K. Jain +1 more
TL;DR: The role of oxidative stress in the pathogenesis of obesity and its associated risk factors, the role of dysfunctional adipose tissue in development of these risk Factors, and potential strategies to regulate body weight loss/gain for better health benefits are highlighted.
Animal models of obesity and diabetes mellitus
Maximilian Kleinert,Christoffer Clemmensen,Susanna M. Hofmann,Mary Courtney Moore,Simone Renner,Stephen C. Woods,Peter Huypens,Johannes Beckers,Martin Hrabé de Angelis,Annette Schürmann,Mostafa Bakhti,Martin Klingenspor,Mark L. Heiman,Alan D. Cherrington,Michael Ristow,Heiko Lickert,Eckhard Wolf,Peter J. Havel,Timo D. Müller,Matthias H. Tschöp +19 more
TL;DR: This Review consolidates the key information on the currently available animal models of obesity and diabetes and highlights the advantages, limitations and important caveats of each of these models.
Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
Robert H. Eckel,Steven E. Kahn,Ele Ferrannini,Allison B. Goldfine,David M. Nathan,Michael W. Schwartz,Robert J. Smith,Steven R. Smith +7 more
TL;DR: Improved understanding of how obesity relates to type 2 diabetes may help advance effective and cost-effective interventions for both conditions, including more tailored therapy.
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
TL;DR: The cellular functions of ER are reviewed, how perturbation of ER homeostasis contributes to metabolic dysregulation and potential causative mechanisms of ER stress in obesity are considered, and a conceptual framework of metabolic roundabout is suggested to integrate key mechanisms of insulin resistance and metabolic diseases.
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Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
Robert H. Eckel,Steven E. Kahn,Ele Ferrannini,Allison B. Goldfine,David M. Nathan,Michael W. Schwartz,Robert J. Smith,Steven R. Smith +7 more
TL;DR: Improved understanding of how obesity relates to type 2 diabetes may help advance effective and cost-effective interventions for both conditions, including more tailored therapy.
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Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.
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