Journal Article10.1016/J.EXGER.2020.110870
Mitochondrial dynamics and metabolism in induced pluripotency.
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TL;DR: Recent data from different laboratories showing how these processes are controlled during the phenotypic transformation of a somatic cell into a pluripotent stem cell will be discussed.
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About: This article is published in Experimental Gerontology. The article was published on 01 May 2020. The article focuses on the topics: Reprogramming & Induced pluripotent stem cell.
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Citations
Functional genomics reveals a bmp driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming (oral presentation)
P Samavarchi Tehrani,A Golipour,L David,H Sung,T Beyer,A Datti,K Woltjen,A Nagy,J L Wrana +8 more
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TL;DR: In this article, the authors explored the molecular mechanisms underlying the reprogramming process by exploiting a secondary mouse embryonic fibroblast model that forms iPSCs with high efficiency upon inducible expression of Oct4, Klf4, c-Myc, and Sox2.
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- 01 Sep 2011
TL;DR: The Lin28/let-7 pathway is established as a central regulator of mammalian glucose metabolism and enriched for genes containing SNPs associated with type 2 diabetes and control of fasting glucose in human genome-wide association studies.
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Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man
TL;DR: In this paper, the authors discuss the mechanisms of reactive oxygen species (ROS) generation and regulation, current understanding of ROS functions in the maintenance of adult and embryonic stem cells, as well as in the process of cell reprogramming to a pluripotent state.
Metformin: Sentinel of the Epigenetic Landscapes That Underlie Cell Fate and Identity
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TL;DR: The biguanide metformin is the first drug to be tested as a gerotherapeutic in the clinical trial TAME (Targeting Aging with Metformin), and it remains a challenge to confirm if regulatory changes in higher-order genomic organizers can connect the capacity of met formin to dynamically regulate the three-dimensional nature of epigenetic landscapes with the 4th dimension, the aging time.
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“Betwixt Mine Eye and Heart a League Is Took” The Progress of Induced Pluripotent Stem-Cell-Based Models of Dystrophin-Associated Cardiomyopathy
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