Journal Article10.1016/J.EXGER.2020.110870
Mitochondrial dynamics and metabolism in induced pluripotency.
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TL;DR: Recent data from different laboratories showing how these processes are controlled during the phenotypic transformation of a somatic cell into a pluripotent stem cell will be discussed.
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About: This article is published in Experimental Gerontology. The article was published on 01 May 2020. The article focuses on the topics: Reprogramming & Induced pluripotent stem cell.
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References
The Expression of Mitochondrial DNA Transcription Factors during Early Cardiomyocyte In Vitro Differentiation from Human Embryonic Stem Cells
Justin C. St. John,João Ramalho-Santos,Heather L. Gray,Patti Petrosko,Vanesa Y. Rawe,Christopher S. Navara,Calvin Simerly,Gerald Schatten +7 more
TL;DR: Analysis of the proliferation of mitochondria and the expression of mtDNA-specific transcription factors in undifferentiated, migratory embryonic stem cells and spontaneously derived cardiomyocytes shows that final embryonic stem cell commitment may be influenced by mitochondrial proliferation and mtDNA transcription.
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α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
Tara TeSlaa,Andrea C. Chaikovsky,Inna Lipchina,Sandra L. Escobar,Konrad Hochedlinger,Jing Huang,Thomas G. Graeber,Daniel Braas,Michael A. Teitell +8 more
TL;DR: αKG promotion of self-renewal or differentiation depending on the pluripotent state is supported, and αKG induced, and succinate impaired, global histone and DNA demethylation in primed PSCs.
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Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells
Shugo Tohyama,Shugo Tohyama,Jun Fujita,Takako Hishiki,Tomomi Matsuura,Fumiyuki Hattori,Rei Ohno,Hideaki Kanazawa,Tomohisa Seki,Kazuaki Nakajima,Yoshikazu Kishino,Marina Okada,Akinori Hirano,Takuya Kuroda,Satoshi Yasuda,Yoji Sato,Shinsuke Yuasa,Motoaki Sano,Makoto Suematsu,Keiichi Fukuda +19 more
TL;DR: This distinguishing feature of hPSC metabolism allows preparation of clinical-grade cell sources free of undifferentiated hPSCs, which prevents tumor formation during stem cell therapy.
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The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response
TL;DR: It is demonstrated that IF1 overexpression in colon cancer cells triggers mitochondrial hyperpolarization and the subsequent production of superoxide radical, a reactive oxygen species (ROS), which provides evidence linking the activity of a mitochondrial protein with retrograde signaling to the nucleus to promote cellular proliferation and survival.
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Pluripotent stem cell energy metabolism: an update
Tara TeSlaa,Michael A. Teitell +1 more
TL;DR: Key features of PSC energy metabolism research in mice and man are explored and the impact this work is starting to have on the understanding of early development, disease modeling, and potential therapeutic applications are explored.