Journal Article10.1016/J.EXGER.2020.110870
Mitochondrial dynamics and metabolism in induced pluripotency.
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TL;DR: Recent data from different laboratories showing how these processes are controlled during the phenotypic transformation of a somatic cell into a pluripotent stem cell will be discussed.
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About: This article is published in Experimental Gerontology. The article was published on 01 May 2020. The article focuses on the topics: Reprogramming & Induced pluripotent stem cell.
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Citations
c-MYC Triggers Lipid Remodelling During Early Somatic Cell Reprogramming to Pluripotency.
Javier Prieto,Javier Prieto,Juan Carlos García-Cañaveras,Marian León,Ramon Sendra,Xavier Ponsoda,Juan Carlos Izpisua Belmonte,Agustín Lahoz,Josema Torres +8 more
TL;DR: The role of the reprogramming factors in metabolic rewiring and mitochondrial dynamics remodelling are hallmarks of cell reprogrammings, but the roles of these factors in these changes are not fully understood as mentioned in this paper.
Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency
TL;DR: It is found that mitochondria and ROS levels due course of the reprogramming tightly correlate with each other, both reaching peak by day 3 and significantly declining by day 10 of the process, substantiating the paradigm that balanced levels of oxidative phosphorylation have to be maintained on the route to pluripotency.
Microtubule-dependent subcellular organisation of pluripotent cells.
TL;DR: In this article, the role of microtubule organization and micro-tubule-dependent events required for the formation of pluripotent cells in vivo by deciphering the process of early embryogenesis: from fertilization to blastocyst.
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Emerging roles of mitochondria in animal regeneration
TL;DR: In this article , the authors reviewed findings related to mitochondrial involvement in animal regeneration and emphasized the impact of defects and perturbation in mitochondria resulting in regeneration failure. But, most studies to date have focused on cellular and tissue regeneration.
OMA1 High-Throughput Screen Reveals Protease Activation by Kinase Inhibitors.
TL;DR: In this paper, the authors introduced a scalable, cellular OMA1 protease assay suitable for high-throughput drug screening, which utilizes an engineered luciferase targeted to the inner membrane as artificial OMA 1 substrate.
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References
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
TL;DR: This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types and regulates regulation of these fluxes by cellular mediators of signal transduction and gene expression.
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