Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity.
Laudiene Evangelista Meyer,Lilia Bender Machado,Ana Paula S. A. Santiago,Wagner Seixas da-Silva,Fernanda G. De Felice,Oliver Holub,Marcus F. Oliveira,Antonio Galina +7 more
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TL;DR: The results presented here indicate that mitochondrial kinase activity performed a key role as a preventive antioxidant against oxidative stress, reducing mitochondrial ROS generation through an ADP-recycling mechanism.
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About: This article is published in Journal of Biological Chemistry. The article was published on 08 Dec 2006. and is currently open access. The article focuses on the topics: Mitochondrial ROS & Kinase activity.
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Citations
The Potential Role of Creatine in Vascular Health.
TL;DR: In this article, the potential effects of creatine on cardiovascular disease (CVD), the leading cause of mortality, are discussed. But, despite the abundance of evidence supporting the ergogenic benefits of creatine supplementation, recent evidence suggests a far broader application for creatine within various myopathies, neurodegenerative diseases, and other pathologies.
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Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.
TL;DR: The data suggest that AK2 is indispensable for neutrophil differentiation and indicate a possible causative link between AK2 deficiency and neutropenia in RD.
Mg(++) requirement for MtHK binding, and Mg(++) stabilization of mitochondrial membranes via activation of MtHK & MtCK and promotion of mitochondrial permeability transition pore closure: A hypothesis on mechanisms underlying Mg(++)'s antioxidant and cytoprotective effects.
TL;DR: It is proposed that magnesium supplementation may provide cytoprotective effects in the treatment of some degenerative diseases and cytopathies with high intracellular [Ca(++)]/ [Mg(++] ratio at these sites, whether of genetic, developmental, drug induced, ischemic, immune based, toxic, or infectious etiology.
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Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime.
Catherine Bellissimo,Luca J. Delfinis,Meghan C. Hughes,Patrick C. Turnbull,Shivam Gandhi,S. N. DiBenedetto,Fasih A. Rahman,Peyman Tadi,Christina A Amaral,Ali Dehghani,James N. Cobley,Joe Quadrilatero,Uwe Schlattner,Christopher G.R. Perry +13 more
TL;DR: Olesoxime was used to prevent early stage mitochondrial stress in limb and respiratory muscle from Duchenne muscular dystrophy (DMD) mice using a proof-of-concept short-term regimen spanning 10-28 days of age as discussed by the authors .
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Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult.
David Kolar,Milada Gresikova,Petra Waskova-Arnostova,Barbara Elsnicova,Jana Kohutova,Daniela Hornikova,Pavel Vebr,Jan Neckar,Tereza Blahova,Dita Kasparova,Jiri Novotny,Frantisek Kolar,Olga Novakova,Jitka Zurmanova +13 more
TL;DR: The Akt/HK2 pathway is likely to play a role in the development of a cardioprotective phenotype of CNH by preventing the detachment of HK2 from mitochondria at reperfusion period and decreases the Bax/Bcl-2 ratio during I/R insult, thereby lowering the probability of apoptosis activation in the mitochondrial compartment.
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