Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity.
Laudiene Evangelista Meyer,Lilia Bender Machado,Ana Paula S. A. Santiago,Wagner Seixas da-Silva,Fernanda G. De Felice,Oliver Holub,Marcus F. Oliveira,Antonio Galina +7 more
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TL;DR: The results presented here indicate that mitochondrial kinase activity performed a key role as a preventive antioxidant against oxidative stress, reducing mitochondrial ROS generation through an ADP-recycling mechanism.
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About: This article is published in Journal of Biological Chemistry. The article was published on 08 Dec 2006. and is currently open access. The article focuses on the topics: Mitochondrial ROS & Kinase activity.
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Citations
Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology
Holger Lenz,Melanie Schmidt,Vivienne Welge,Thomas Kueper,Uwe Schlattner,Theo Wallimann,Hans-Peter Elsässer,Klaus-Peter Wittern,Horst Wenck,Franz Staeb,Thomas Blatt +10 more
TL;DR: The mitochondrial CK isoform appears to play the most crucial role in maintaining cell viability by stabilizing contact sites between inner and outer mitochondrial membranes and maintaining local metabolite channeling, thus avoiding transition pore opening which eventually results in activation of caspase cell-death pathways.
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TL;DR: The laser effect on lipopolysaccharide (LPS)-induced cytokine secretion and HDAC activity in U937 cells under oxidative stress is investigated and low-level laser therapy (LLLT) has been proven to be an anti-inflammatory.
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Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy – Creatine prophylaxis and the need for multi-organ protection
TL;DR: Data is presented suggesting that dietary creatine supplementation during pregnancy may be an effective prophylaxis that can protect the fetus from the multi-organ consequences of severe hypoxia at birth.
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