Journal Article10.1016/S0197-0186(01)00122-X
Mitochondrial contributions to tissue damage in stroke.
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TL;DR: Although evaluating mitochondrial properties in intact brain is difficult, evidence for several potentially deleterious responses to cerebral ischemia or post-ischemic reperfusion have been obtained from investigations using animal models of stroke.
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About: This article is published in Neurochemistry International. The article was published on 01 May 2002. The article focuses on the topics: Reperfusion injury & Mitochondrial permeability transition pore.
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Citations
Protective functions of taurine against experimental stroke through depressing mitochondria-mediated cell death in rats
TL;DR: It is demonstrated that preserving the mitochondrial function and blocking the mitochondria-mediated cell death pathway may be one mechanism of taurine’s action against brain ischemia.
81
SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury
Sergei A. Novgorodov,Christopher L. Riley,Jarryd A. Keffler,Jin Yu,Mark S. Kindy,Wendy B. Macklin,David B. Lombard,Tatyana I. Gudz,Tatyana I. Gudz +8 more
TL;DR: Reports that SIRT3 regulates mitochondrial ceramide biosynthesis via deacetylation of ceramide synthase (CerS) 1, 2, and 6 and gene ablation reduced the brain injury after IR suggest an important role of Sirt3 in mitochondrial dysfunction and brain injuries after experimental stroke.
76
Invited review: decoding the microRNA response to hypoxia
TL;DR: Recent discoveries that have boosted the understanding of miRNA regulation of hypoxia are reviewed and where future breakthroughs in this area may be made are discussed.
74
Neuroprotective Effect of Punicalagin against Cerebral Ischemia Reperfusion-induced Oxidative Brain Injury in Rats
TL;DR: Results suggested that supplementation of PG treatment effectively ameliorates the cerebral ischemia/reperfusion induced oxidative damage by virtue of its antioxidant potential.
73
Effects of hypoxia exposure on hepatic cytochrome P450 1A (CYP1A) expression in Atlantic croaker: molecular mechanisms of CYP1A down-regulation.
Md. Saydur Rahman,Peter Thomas +1 more
TL;DR: The present study provides the first evidence of a role for antioxidants in hepatic eNOS and IL-1β regulation in aquatic vertebrates during hypoxic stress and suggests that hypoxia-induced down-regulation of CYP1A is due to alterations of NO and oxidant status, and cellular IL- 1β and HIF-α levels.
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