Journal Article10.1016/J.BIOTECHADV.2012.09.005
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
Jan Gruber,Sheng Fong,Ce-Belle Chen,Sialee Yoong,Giorgia Pastorin,Sebastian Schaffer,Irwin K. Cheah,Barry Halliwell +7 more
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TL;DR: This review explores strategies of targeting mitochondria to reduce mitochondrial oxidative damage with the aim of preventing or delaying age-dependent decline in mitochondrial function and some of the resulting pathologies.
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About: This article is published in Biotechnology Advances. The article was published on 01 Sep 2013. The article focuses on the topics: MitoQ.
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Citations
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.
TL;DR: Multiple chemically different molecular strategies have been developed as delivery tools that offer broad opportunities for mitochondrial manipulation, including molecules conjugated with lipophilic cations or rhodamine, conjugates of plant alkaloids, amino-acid- and peptide-based compounds, and liposomes.
264
The Mitochondrial Free Radical Theory of Aging
TL;DR: The information available supports a mitochondrial free radical theory of aging focused on low generation of endogenous damage and low sensitivity of membranes to oxidation in long-lived animals.
209
Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?
TL;DR: Significant progress in the field of antioxidant research is highlighted, including the fine-tuned equilibrium between antioxidant defenses and free radical production, the lack of specific antioxidant target(s), and the inherent difficulty in delivering antioxidants where they are needed.
193
Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models
Noemí Cárdenas-Rodríguez,Bernardino Huerta-Gertrudis,Liliana Rivera-Espinosa,Hortencia Montesinos-Correa,Cindy Bandala,Liliana Carmona-Aparicio,Elvia Coballase-Urrutia +6 more
TL;DR: A review of experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy is presented.
141
Small molecules as therapeutic drugs for Alzheimer's disease
TL;DR: Advantages and disadvantages of small molecules, their ability to mitigate A&bgr; induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss are discussed.
119
References
Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin−TEMPO Conjugates
Peter Wipf,Jingbo Xiao,Jianfei Jiang,Natalia A. Belikova,Vladimir A. Tyurin,Mitchell P. Fink,Valerian E. Kagan +6 more
TL;DR: Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis.
Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans.
Juewon Kim,Mayumi Takahashi,Takahiko Shimizu,Takuji Shirasawa,Masashi Kajita,Atsuhiro Kanayama,Yusei Miyamoto +6 more
TL;DR: The in vitro dose-dependent quenching of O(2)(-) and H(2)O(2), indicating that nano-Pt is a more potent SOD/catalase mimetic than EUK-8, prolonged the worm lifespan, regardless of thermotolerance or dietary restriction.
Mitochondria-targeted peptide antioxidants: novel neuroprotective agents
TL;DR: The development of a novel class of mitochondria-targeted antioxidants that can protect mitochondria against oxidative stress and prevent neuronal cell death in animal models of stroke, Parkinson’s disease, and amyotrophic lateral sclerosis is summarized.
The mitochondrial free radical theory of ageing--where do we stand?
TL;DR: A critical review of a version of the free radical theory of ageing, focusing on mitochondria as source as well as target of ROS, finds that many of the original assumptions are questionable, while on some critical issues further refinements in techniques are required.
Mitochondrial uncouplers with an extraordinary dynamic range
Phing-How Lou,Birgit Sehested Hansen,Preben H. Olsen,Soren Tullin,Michael P. Murphy,Martin D. Brand +5 more
TL;DR: The wide dynamic range of these weak uncouplers in isolated mitochondria and intact cells reveals a novel allosteric activation of proton transport through the adenine nucleotide translocase and provides a promising starting point for designing safer uncouples for obesity therapy.
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