Journal Article10.1016/J.BIOTECHADV.2012.09.005
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
Jan Gruber,Sheng Fong,Ce-Belle Chen,Sialee Yoong,Giorgia Pastorin,Sebastian Schaffer,Irwin K. Cheah,Barry Halliwell +7 more
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TL;DR: This review explores strategies of targeting mitochondria to reduce mitochondrial oxidative damage with the aim of preventing or delaying age-dependent decline in mitochondrial function and some of the resulting pathologies.
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About: This article is published in Biotechnology Advances. The article was published on 01 Sep 2013. The article focuses on the topics: MitoQ.
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Citations
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.
TL;DR: Multiple chemically different molecular strategies have been developed as delivery tools that offer broad opportunities for mitochondrial manipulation, including molecules conjugated with lipophilic cations or rhodamine, conjugates of plant alkaloids, amino-acid- and peptide-based compounds, and liposomes.
264
The Mitochondrial Free Radical Theory of Aging
TL;DR: The information available supports a mitochondrial free radical theory of aging focused on low generation of endogenous damage and low sensitivity of membranes to oxidation in long-lived animals.
209
Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?
TL;DR: Significant progress in the field of antioxidant research is highlighted, including the fine-tuned equilibrium between antioxidant defenses and free radical production, the lack of specific antioxidant target(s), and the inherent difficulty in delivering antioxidants where they are needed.
193
Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models
Noemí Cárdenas-Rodríguez,Bernardino Huerta-Gertrudis,Liliana Rivera-Espinosa,Hortencia Montesinos-Correa,Cindy Bandala,Liliana Carmona-Aparicio,Elvia Coballase-Urrutia +6 more
TL;DR: A review of experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy is presented.
141
Small molecules as therapeutic drugs for Alzheimer's disease
TL;DR: Advantages and disadvantages of small molecules, their ability to mitigate A&bgr; induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss are discussed.
119
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TL;DR: The lack of difference in maximal life spans among the Positive- TG, Negative-TG, and UCP3KO suggests that U CP3 does not significantly affect longevity in mice.
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An investigation of the effects of MitoQ on human peripheral mononuclear cells
TL;DR: The results of this investigation suggest that mitoQ may have anti-immunosenescent potential, as it significantly reduced endogenous levels of DNA damage.
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Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
Vladimir N. Anisimov,Khavinson Vladimir Kh,Irina G. Popovich,Mark A. Zabezhinski,Irina Alimova,Svetlana V Rosenfeld,Natalia Yu. Zavarzina,Anna V. Semenchenko,Anatoli I. Yashin +8 more
TL;DR: The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice, but it slowed down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells.
Caged mitochondrial uncouplers that are released in response to hydrogen peroxide
Caroline Quin,Linsey Robertson,Stephen J. McQuaker,Nicholas C. Price,Martin D. Brand,Richard C. Hartley +5 more
TL;DR: Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncoupler 2,4-dinitrophenol and carbonylcyanide p-trifluoromethoxyphenylhydrazone from caged states.
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Dichloroacetate Modulates the Oxidative Stress and Inflammatory Response to Exercise in COPD
Evi M. Mercken,LD Calvert,Sally J Singh,Geja J. Hageman,Annemie M. W. J. Schols,Michael C Steiner +5 more
TL;DR: Improved performance after a pharmacologic intervention known to activate PDC was accompanied by an enhanced IL-6 response and a limited reduction in exercise-induced systemic oxidative stress.
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