Journal Article10.1016/J.BIOTECHADV.2012.09.005
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
Jan Gruber,Sheng Fong,Ce-Belle Chen,Sialee Yoong,Giorgia Pastorin,Sebastian Schaffer,Irwin K. Cheah,Barry Halliwell +7 more
133
TL;DR: This review explores strategies of targeting mitochondria to reduce mitochondrial oxidative damage with the aim of preventing or delaying age-dependent decline in mitochondrial function and some of the resulting pathologies.
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About: This article is published in Biotechnology Advances. The article was published on 01 Sep 2013. The article focuses on the topics: MitoQ.
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Citations
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.
TL;DR: Multiple chemically different molecular strategies have been developed as delivery tools that offer broad opportunities for mitochondrial manipulation, including molecules conjugated with lipophilic cations or rhodamine, conjugates of plant alkaloids, amino-acid- and peptide-based compounds, and liposomes.
264
The Mitochondrial Free Radical Theory of Aging
TL;DR: The information available supports a mitochondrial free radical theory of aging focused on low generation of endogenous damage and low sensitivity of membranes to oxidation in long-lived animals.
209
Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?
TL;DR: Significant progress in the field of antioxidant research is highlighted, including the fine-tuned equilibrium between antioxidant defenses and free radical production, the lack of specific antioxidant target(s), and the inherent difficulty in delivering antioxidants where they are needed.
193
Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models
Noemí Cárdenas-Rodríguez,Bernardino Huerta-Gertrudis,Liliana Rivera-Espinosa,Hortencia Montesinos-Correa,Cindy Bandala,Liliana Carmona-Aparicio,Elvia Coballase-Urrutia +6 more
TL;DR: A review of experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy is presented.
141
Small molecules as therapeutic drugs for Alzheimer's disease
TL;DR: Advantages and disadvantages of small molecules, their ability to mitigate A&bgr; induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss are discussed.
119
References
Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes
TL;DR: A demonstration of mitochondrial matrix delivery and the visualization of mitochondrial genes (mtDNA) in living cells using the MITO-Porter is provided.
74
Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
Yih-Woei C. Fridell,Melissa Hoh,Orsolya Kréneisz,Suzanne Hosier,Chengyi Chang,Dane Scantling,Daniel K. Mulkey,Stephen L. Helfand +7 more
- 21 Jul 2009
TL;DR: A role for UCP in adult Drosophila IPCs is demonstrated in influencing systemic insulin signaling and longevity by a mechanism that may involve KATP channels.
74
Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles
TL;DR: A surfactant-free nanoprecipitation procedure is presented that in combination with a novel purification step enables the synthesis of individual and purified CoQ 10-loaded nanoparticles, which are promising as sustained drug delivery devices due to their extended CoQ10 release.
71
Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex.
Ben-zhan Zhu,Li Mao,Rui-Mei Fan,Jun-Ge Zhu,Ying-Nan Zhang,Jing Wang,Balaraman Kalyanaraman,Balz Frei +7 more
TL;DR: It is concluded that ergothioneine is a potent, natural sulfur-containing antioxidant that prevents copper-dependent oxidative damage to biological macromolecules by forming a redox-inactive ergothsioneine-copper complex.
71
Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells.
Valérie Desquiret,Dominique Loiseau,Caroline Jacques,Olivier Douay,Yves Malthièry,Patrick Ritz,Damien Roussel +6 more
TL;DR: It is proposed that chronic respiratory uncoupling may constitute an internal bioenergetic signal, which would initiate a coordinated increase in nuclear respiratory gene expression, which ultimately drives mitochondrial metabolic adaptation within cells.
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