Journal Article10.1016/J.BIOTECHADV.2012.09.005
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
Jan Gruber,Sheng Fong,Ce-Belle Chen,Sialee Yoong,Giorgia Pastorin,Sebastian Schaffer,Irwin K. Cheah,Barry Halliwell +7 more
133
TL;DR: This review explores strategies of targeting mitochondria to reduce mitochondrial oxidative damage with the aim of preventing or delaying age-dependent decline in mitochondrial function and some of the resulting pathologies.
read more
About: This article is published in Biotechnology Advances. The article was published on 01 Sep 2013. The article focuses on the topics: MitoQ.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.
TL;DR: Multiple chemically different molecular strategies have been developed as delivery tools that offer broad opportunities for mitochondrial manipulation, including molecules conjugated with lipophilic cations or rhodamine, conjugates of plant alkaloids, amino-acid- and peptide-based compounds, and liposomes.
264
The Mitochondrial Free Radical Theory of Aging
TL;DR: The information available supports a mitochondrial free radical theory of aging focused on low generation of endogenous damage and low sensitivity of membranes to oxidation in long-lived animals.
209
Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?
TL;DR: Significant progress in the field of antioxidant research is highlighted, including the fine-tuned equilibrium between antioxidant defenses and free radical production, the lack of specific antioxidant target(s), and the inherent difficulty in delivering antioxidants where they are needed.
193
Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models
Noemí Cárdenas-Rodríguez,Bernardino Huerta-Gertrudis,Liliana Rivera-Espinosa,Hortencia Montesinos-Correa,Cindy Bandala,Liliana Carmona-Aparicio,Elvia Coballase-Urrutia +6 more
TL;DR: A review of experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy is presented.
141
Small molecules as therapeutic drugs for Alzheimer's disease
TL;DR: Advantages and disadvantages of small molecules, their ability to mitigate A&bgr; induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss are discussed.
119
References
Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
Allison C. Gates,Carlos Bernal-Mizrachi,Sharon L. Chinault,Chu Feng,Jochen G. Schneider,Trey Coleman,James P. Malone,Raymond R. Townsend,Manu V. Chakravarthy,Clay F. Semenkovich +9 more
TL;DR: It is reported that skeletal muscle respiratory uncoupling due to UCP1 expression diminishes age-related disease in three mouse models and accelerating metabolism in skeletal muscle does not appear to impact aging but may delay age- related disease.
114
Uncoupling protein-2 regulates lifespan in mice
Zane B. Andrews,Tamas L. Horvath +1 more
TL;DR: It is shown that increased mitochondrial uncoupling activity of different tissues predicts longer lifespan of rats compared with mice, and UCP2 has a beneficial influence on cell and tissue function leading to increased lifespan.
110
Cu(I)–Glutathione complex: A potential source of superoxide radicals generation
Hernán Speisky,Maritza Gómez,Catalina Carrasco-Pozo,Edgar Pastene,Camilo López-Alarcón,Claudio Olea-Azar +5 more
TL;DR: In solutions containing the Cu(I)-glutathione complex, oxygen is continually reduced into superoxide, and that-in absence of interceptors-the latter radicals are quantitatively re-oxidized into molecular oxygen.
110
Newly developed strategies for multifunctional mitochondria-targeted agents in cancer therapy
TL;DR: Multifunctional nanostructures or multifunctional chemical compounds further broaden the current concept of tumor targeting and provide alternative solutions for mitochondrially targeted cancer therapy.
110
Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains
Matthew Whiteman,Jeffrey S. Armstrong,Nam Sang Cheung,Jia-Ling Siau,Peter Rose,Jan-Thorsten Schantz,Dean P. Jones,Barry Halliwell +7 more
TL;DR: The data show, for the first time, that peroxynitrite induces mitochondrial dysfunction in cells via a calcium‐dependent process that leads to caspase‐independent apoptosis mediated by calpains.
109
Related Papers (5)
Vladimir P. Skulachev,Vladimir N. Anisimov,Yuri N. Antonenko,Lora E. Bakeeva,Boris V. Chernyak,V.P. Erichev,Oleg F. Filenko,Natalya I. Kalinina,Valery I. Kapelko,N. G. Kolosova,Boris P. Kopnin,Galina A. Korshunova,Mikhail R. Lichinitser,Lidia A. Obukhova,Elena G. Pasyukova,Oleg I. Pisarenko,Vitaly A. Roginsky,Enno K. Ruuge,Ivan I. Senin,Inna I. Severina,Maxim V. Skulachev,Irina Spivak,Vadim N. Tashlitsky,Vsevolod A. Tkachuk,Mikhail Yu. Vyssokikh,Lev S. Yaguzhinsky,Dmitry B. Zorov +26 more