Mitochondria in innate immune responses
1.2K
TL;DR: This work reviews the emerging knowledge about the roles of mitochondria in innate immunity and suggests mitochondria appear to function as centrally positioned hubs in the innate immune system.
read more
Abstract: The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Intratumoral Administration Immunogenic Exosomes can Modify Tumor Immune Microenvironment
Arman Kalami,Zahra Poursalehi,Farzaneh Hosseini Gharalari,Hossein Molavi,Mohammad Tollabi,Behnam Nasiri-Motlagh,Mehdi Shahgolzari,Ahmad Yari Khosroshahi +7 more
- 02 Feb 2024
TL;DR: Intratumoral exosomes can modify the tumor immune microenvironment and have therapeutic effects in triple-negative breast cancer.
Mitochondrial Dysfunction-Triggered Innate Immune Response and Its Therapeutic Implications
Yinghong He,Bo Shen,Xiang Zhou +2 more
- 22 Oct 2024
TL;DR: Mitochondrial dysfunction triggers innate immune response through mtDNA release, activating cGAS-STING and NLRP3 inflammasome pathways, leading to inflammation, autoimmune disorders, and cancer, with therapeutic potential through targeting these pathways with agonists or inhibitors.
Metatranscriptome analysis reveals bacterial symbiont contributions to lower termite physiology and potential immune functions.
TL;DR: This study presents the most complete bacterial metatranscriptome from a lower termite and provides a framework on which to build a more complete model of termite-symbiont interactions including, but not limited to, digestion and pathogen defense.
Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity.
TL;DR: Examination of existing knowledge on the involvement of mitochondrial DNA in the anti-microbial immunity by modulating the various immune signaling pathways suggests that this cytosolic mitochondrial DNA seems to be essential in triggering innate anti- microbial immunity.
Inflammation, Advancing Age and Nutrition
Irfan Rahman,Debasis Bagchi +1 more
TL;DR: This book provides a comprehensive overview of the integrated impact of cellular, molecular, and lifestyle factors on premature aging, inflammation, and disease, exploring personalized nutrition and pharmacological interventions to reverse these conditions.
References
How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
A role for mitochondria in NLRP3 inflammasome activation
TL;DR: It is shown that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome, and may explain the frequent association of mitochondrial damage with inflammatory diseases.
4.8K
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
TL;DR: The identification of a novel protein termed MAVS (mitochondrial antiviral signaling), which mediates the activation of NF-kappaB and IRF 3 in response to viral infection, and implicates a new role of mitochondria in innate immunity.
3.1K
NOX enzymes and the biology of reactive oxygen
TL;DR: Professional phagocytes generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of microbicidal mechanisms, leading to the concept that ROS are 'intentionally' generated in these cells with distinctive cellular functions related to innate immunity, signal transduction and modification of the extracellular matrix.
3.1K
Related Papers (5)
Kenichi Shimada,Timothy R. Crother,Justin Karlin,Jargalsaikhan Dagvadorj,Norika Chiba,Shuang Chen,V. Krishnan Ramanujan,Andrea J. Wolf,Laurent Vergnes,David M. Ojcius,Altan Rentsendorj,Mario Vargas,Candace R. Guerrero,Yinsheng Wang,Katherine A. Fitzgerald,David M. Underhill,Terrence Town,Moshe Arditi +17 more