Journal Article10.1002/BIOT.200800015
Mitochondria and ageing in Drosophila
27
TL;DR: The fruitfly Drosophila melanogaster is a well‐suited organism to study ageing as it is relatively short‐lived, mainly composed of post‐mitotic cells, has sequenced nuclear and mitochondrial genomes, and multiple genetic tools are available.
read more
Abstract: Studies in different organisms have revealed that ageing is a complex process involving a tight regulation of gene expression. Among other features, ageing organisms generally display an increased oxidative stress and a decreased mitochondrial function. The increase in oxidative stress can be attributable to reactive oxygen species, which are mainly produced by mitochondria as a by-product of energy metabolism. Consistent with these data, mitochondria have been suggested to play a significant role in lifespan determination. The fruitfly Drosophila melanogaster is a well-suited organism to study ageing as it is relatively short-lived, mainly composed of post-mitotic cells, has sequenced nuclear and mitochondrial genomes, and multiple genetic tools are available. It has been used in genome-wide studies to unveil the molecular signature of ageing, in different feeding and dietary restriction protocols and in overexpression and down-regulation studies to examine the effect of specific compounds or genes/proteins on lifespan. Here we review the various features linking mitochondria and ageing in Drosophila melanogaster.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
Alessandra Valerio,Giuseppe D'Antona,Enzo Nisoli +2 more
- 30 Apr 2011
TL;DR: Observations from human studies supporting the exciting hypothesis that dietary BCAA enriched mixture supplementation might be a health-promoting strategy in aged patients at risk are summarized.
Heat shock proteins and Drosophila aging
TL;DR: In this article, the role of heat shock proteins (Hsps) in aging has been studied in Drosophila, and their expression correlates with, and sometimes predicts, life span, making them ideal biomarkers of aging.
163
The Interplay Between Respiratory Supercomplexes and ROS in Aging.
Maria Luisa Genova,Giorgio Lenaz +1 more
TL;DR: This review critically examines the role of ROS in aging in the light of recent advances on the relationship between mitochondrial structure and function and proposes that under physiological conditions the dynamic nature of SCs reversibly controls the generation of ROS as signals involved in mitochondrial-nuclear communication.
116
Experimental Selection for Drosophila Survival in Extremely High O2 Environments
Huiwen W. Zhao,Dan Zhou,Victor Nizet,Victor Nizet,Victor Nizet,Gabriel G. Haddad,Gabriel G. Haddad +6 more
TL;DR: This study generated a Drosophila melanogaster strain that can live and reproduce in very high O2 environments (90% O2), a lethal condition to naïve flies, and demonstrated that tolerance to hyperoxia was heritable in these flies and that thesehyperoxia-selected flies exhibited phenotypic differences from naïve flies.
Detection ofdeletions inthemitochondrial genome of Caenorhabditis elegans
Gerald Z. Hertz
- 01 Jan 1994
TL;DR: In this article, an aging population of Caenorhabditis elegans was examined via a PCR assay to determine if deletions inthemitochondrial genome occur in the nematode.
74
References
Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage.
TL;DR: It is demonstrated that ROS affect the mitochondrial complex I activity via oxidative damage of cardiolipin which is required for the functioning of this multisubunit enzyme complex.
374
An antioxidant system required for host protection against gut infection in Drosophila.
Eun Mi Ha,Chun Taek Oh,Ji-Hwan Ryu,Yun Soo Bae,Sang Won Kang,In Hwan Jang,In Hwan Jang,Paul T. Brey,Won-Jae Lee +8 more
TL;DR: It is shown that in Drosophila an extracellular immune-regulated catalase (IRC) mediates a key host defense system that is needed during host-microbe interaction in the gastrointestinal tract and implies that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host- microbe interaction on gastrointestinal tract.
351
Genome-wide study of aging and oxidative stress response in Drosophila melanogaster
TL;DR: It is suggested that free radicals play an important role in regulating transcript levels in aging but that they are not the only factors.
345
Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA
Shuji Mita,Rosario Rizzuto,Carlos T. Moraes,Sara Shanske,Enrica Arnaudo,Gian Maria Fabrizi,Yasutoshi Koga,Salvatore DiMauro,Eric A. Schon +8 more
TL;DR: Computer analysis showed a correlation between the location of the deletion breakpoints and sequences in human mtDNA similar to the target sequence for Drosophila topoisomerase II.
Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
TL;DR: Observations establish Hsp22 as a key player in cell‐protection mechanisms against oxidative injuries and aging in Drosophila and corroborate the pivotal role of mitochondria in the process of aging.
333