Minireview: adiposity, inflammation, and atherogenesis.
TL;DR: Greater understanding of adipokine regulation should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity.
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Abstract: Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now been shown regulate, directly or indirectly, a number of the processes that contribute to the development of atherosclerosis, including hypertension, endothelial dysfunction, insulin resistance, and vascular remodeling. Several adipokines are preferentially expressed in visceral adipose tissue, and the secretion of proinflammatory adipokines is elevated with increasing adiposity. Not surprisingly, approaches that reduce adipose tissue depots, including surgical fat removal, exercise, and reduced caloric intake, improve proinflammatory adipokine levels and reduce the severity of their resultant pathologies. Systemic adipokine levels can also be favorably altered by treatment with several of the existing drug classes used to treat insulin resistance, hypertension, and hypercholesterolemia. Greater understanding of adipokine regulation, however, should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity.
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References
Angiotensin converting enzyme inhibitors suppress production of tumor necrosis factor-α in vitro and in vivo
Masamitsu Fukuzawa,Jo Satoh,Mikio Sagara,Gen Muto,Yoshiko Muto,Sachiko Nishimura,Shuichi Miyaguchi,Xiao Ling Qiang,Yoshiyuki Sakata,Tetsuya Nakazawa,Fumiko Ikehata,Setsu Ohta,Takayoshi Toyota +12 more
TL;DR: Results indicate that ACE inhibitors such as captopril, delapril and cilazapril have an inhibitory effect on TNF-α production not only in vitro as previously reported, but also in vivo, although relatively high concentrations and large doses were required in this study.
89
Dimethyl sulfoxide modulates NF-kappa B and cytokine activation in lipopolysaccharide-treated murine macrophages.
TL;DR: Results suggest that modulation of NF-kappa B activation may provide a mechanism through which antioxidants protect against endotoxemia in murine models.
80
Plasminogen Activator Inhibitor Type-1 Synthesis and mRNA Expression in HepG2 Cells Are Regulated by VLDL
Luigi Sironi,Luciana Mussoni,L. Prati,Damiano Baldassarre,Marina Camera,Cristina Banfi,Elena Tremoli +6 more
TL;DR: It is shown that the effect of VLDL is mediated by its interaction with the LDL receptor, and may raise PAI-1 antigen levels not only in hypertriglyceridemic states but also in those conditions in which both insulin and V LDL are elevated.
79
Losartan and perindopril effects on plasma plasminogen activator inhibitor-1 and fibrinogen in hypertensive type 2 diabetic patients
Roberto Fogari,Amedeo Mugellini,Annalisa Zoppi,Luca Corradi,Paola Preti,Pierangelo Lazzari,Giuseppe Derosa +6 more
TL;DR: Findings indicate that perindopril but not losartan decreases PAI-1 in hypertensive type 2 diabetic patients, which suggests that the PAi-1 lowering effect is unrelated with AT, receptor blockade and could rather be due to the fact that the endothelial receptors that mediate PA I-1 expression in response to angiotensin II are not type 1 receptor subtypes.
78
Progression of coronary artery disease in young male post-infarction patients is linked to disturbances of carbohydrate and lipoprotein metabolism and to impaired fibrinolytic function
Peter Båvenholm,U de Faire,Christian Landou,Suad Efendic,Jan-Åke Nilsson,Björn Wiman,Anders Hamsten +6 more
TL;DR: Disturbances in carbohydrate and lipoprotein metabolism and impaired fibrinolytic function are associated with progression of coronary artery disease in young male post-infarction patients.
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